Apr 15 Fri 2022
| 12:10 PM | ||||
| 951 | Arizona DiamondbacksZ. Davies -R | +1½ -113 | +192 | O 8½ +100 |
| 952 | New York MetsC. Bassitt -R+1 Markets | -1½ -107 | -210 | U 8½ -120 |
| 01:10 PM | ||||
| 965 | Minnesota TwinsJ. Ryan -R | +1½ -175 | +105 | O 10 -105 |
| 966 | Boston Red SoxN. Pivetta -R+1 Markets | -1½ +155 | -115 | U 10 -115 |
| 05:35 PM | ||||
| 953 | Washington NationalsE. Fedde -R | +1½ -190 | +101 | O 9½ +100 |
| 954 | Pittsburgh PiratesM. Keller -R+1 Markets | -1½ +165 | -111 | U 9½ -120 |
| 05:40 PM | ||||
| 955 | Philadelphia PhilliesZ. Eflin -R | +1½ -195 | +100 | O 7½ -115 |
| 956 | Miami MarlinsP. Lopez -R+1 Markets | -1½ +170 | -110 | U 7½ -105 |
| 06:05 PM | ||||
| 967 | New York YankeesJ. Montgomery -L | -1½ -135 | -197 | O 9½ -110 |
| 968 | Baltimore OriolesJ. Lyles -R+1 Markets | +1½ +115 | +181 | U 9½ -110 |
| 06:07 PM | ||||
| 969 | Oakland AthleticsD. Jefferies -R | +1½ -108 | +175 | O 9½ -110 |
| 970 | Toronto Blue JaysR. Stripling -R+1 Markets | -1½ -112 | -191 | U 9½ -110 |
| 06:10 PM | ||||
| 971 | Tampa Bay RaysD. Rasmussen -R | +1½ -165 | +129 | O 8½ -110 |
| 972 | Chicago White SoxD. Cease -R+1 Markets | -1½ +145 | -139 | U 8½ -110 |
| 06:10 PM | ||||
| 979 | San Francisco GiantsC. Rodon -L | -1½ +110 | -142 | O 8½ +102 |
| 980 | Cleveland GuardiansZ. Plesac -R+1 Markets | +1½ -130 | +131 | U 8½ -122 |
| 07:10 PM | ||||
| 957 | St. Louis CardinalsM. Mikolas -R | +1½ -160 | +138 | O 8 -125 |
| 958 | Milwaukee BrewersF. Peralta -R+1 Markets | -1½ +140 | -149 | U 8 +105 |
| 07:10 PM | ||||
| 975 | Detroit TigersT. Skubal -L | +1½ -170 | +122 | O 8½ -110 |
| 976 | Kansas City RoyalsB. Keller -R+1 Markets | -1½ +150 | -132 | U 8½ -110 |
| 07:40 PM | ||||
| 959 | Chicago CubsM. Stroman -R | +1½ -170 | +112 | O 10 -105 |
| 960 | Colorado RockiesG. Marquez -R+1 Markets | -1½ +150 | -122 | U 10 -115 |
| 08:40 PM | ||||
| 961 | Atlanta BravesK. Wright -R | +1½ -195 | +100 | O 8½ -105 |
| 962 | San Diego PadresM. Gore -L+1 Markets | -1½ +170 | -110 | U 8½ -115 |
| 08:42 PM | ||||
| 977 | Houston AstrosJ. Odorizzi -R | -1½ +130 | -123 | O 8½ -120 |
| 978 | Seattle MarinersM. Gonzales -L+1 Markets | +1½ -150 | +113 | U 8½ +100 |
| 09:10 PM | ||||
| 963 | Cincinnati RedsV. Gutierrez -R | +1½ +101 | +203 | O 9½ +105 |
| 964 | Los Angeles DodgersT. Gonsolin -R+1 Markets | -1½ -121 | -224 | U 9½ -125 |
