Sep 22 Wed 2021
| 12:10 PM | ||||
| 913 | Chicago White SoxR. Lopez -R | -1½ -110 | -157 | O 9 -110 |
| 914 | Detroit TigersC. Mize -R | +1½ -110 | +145 | U 9 -110 |
| 5:10 PM | ||||
| 917 | Kansas City RoyalsC. Hernandez -R | +1½ -194 | -105 | O 8½ -120 |
| 918 | Cleveland IndiansL. Allen -L | -1½ +169 | -105 | U 8½ +100 |
| 5:40 PM | ||||
| 903 | Washington NationalsJ. Gray -R | +1½ -170 | +120 | O 8 -105 |
| 904 | Miami MarlinsE. Hernandez -R | -1½ +150 | -130 | U 8 -115 |
| 6:05 PM | ||||
| 919 | Texas RangersT. Hearn -L | +1½ +114 | +237 | O 8½ -122 |
| 920 | New York YankeesC. Kluber -R | -1½ -134 | -265 | U 8½ +102 |
| 6:05 PM | ||||
| 925 | Baltimore OriolesK. Akin -L | +1½ +111 | +241 | O 8½ +105 |
| 926 | Philadelphia PhilliesZ. Wheeler -R | -1½ -131 | -270 | U 8½ -125 |
| 7:40 PM | ||||
| 907 | Los Angeles DodgersW. Buehler -R | -1½ -125 | -185 | O 10½ -120 |
| 908 | Colorado RockiesG. Marquez -R | +1½ +105 | +170 | U 10½ +100 |
| 8:38 PM | ||||
| 921 | Houston AstrosL. Garcia -R | -1½ -136 | -212 | O 9 -122 |
| 922 | Los Angeles AngelsJ. Junk -R | +1½ +116 | +193 | U 9 +102 |
| 8:40 PM | ||||
| 909 | Atlanta BravesI. Anderson -R | -1½ -118 | -182 | O 9 -115 |
| 910 | Arizona DiamondbacksM. Kelly -R | +1½ -102 | +167 | U 9 -105 |
| 8:40 PM | ||||
| 923 | Seattle MarinersC. Flexen -R | +1½ -170 | +118 | O 8½ +100 |
| 924 | Oakland AthleticsC. Irvin -L | -1½ +150 | -128 | U 8½ -120 |
