Sep 15 Wed 2021
| 12:05 PM | ||||
| 951 | Miami MarlinsT. Rogers -L | -1½ +145 | -119 | O 8½ -108 |
| 952 | Washington NationalsJ. Rogers -L | +1½ -165 | +109 | U 8½ -112 |
| 12:10 PM | ||||
| 979 | Milwaukee BrewersB. Woodruff -R | -1½ -135 | -220 | O 9 -105 |
| 980 | Detroit TigersM. Manning -R | +1½ +115 | +200 | U 9 -115 |
| 2:07 PM | ||||
| 965 | Tampa Bay RaysM. Wacha -R | +1½ -125 | +157 | O 9 -123 |
| 966 | Toronto Blue JaysR. Ray -L | -1½ +105 | -171 | U 9 +103 |
| 3:10 PM | ||||
| 967 | Boston Red SoxT. Houck -R | -1½ +135 | -125 | O 8½ -110 |
| 968 | Seattle MarinersM. Gonzales -L | +1½ -155 | +115 | U 8½ -110 |
| 5:35 PM | ||||
| 953 | Cincinnati RedsV. Gutierrez -R | -1½ +100 | -143 | O 9 -107 |
| 954 | Pittsburgh PiratesM. Keller -R | +1½ -120 | +132 | U 9 -113 |
| 6:05 PM | ||||
| 955 | Chicago CubsA. Mills -R | +1½ -120 | +175 | O 9 -110 |
| 956 | Philadelphia PhilliesR. Suarez -L | -1½ +100 | -191 | U 9 -110 |
| 6:10 PM | ||||
| 957 | St. Louis CardinalsJ. Lester -L | +1½ -160 | +134 | O 8 -120 |
| 958 | New York MetsT. Megill -R | -1½ +140 | -145 | U 8 +100 |
| 6:20 PM | ||||
| 959 | Colorado RockiesA. Senzatela -R | +1½ -115 | +180 | O 9 -105 |
| 960 | Atlanta BravesH. Ynoa -R | -1½ -105 | -196 | U 9 -115 |
| 6:40 PM | ||||
| 971 | Cleveland IndiansC. Quantrill -R | +1½ -186 | +100 | O 9 -120 |
| 972 | Minnesota TwinsG. Jax -R | -1½ +166 | -110 | U 9 +100 |
| 7:05 PM | ||||
| 973 | Houston AstrosJ. Urquidy -R | -1½ -130 | -201 | O 9 -117 |
| 974 | Texas RangersK. Arihara -R | +1½ +110 | +184 | U 9 -103 |
| 7:10 PM | ||||
| 977 | Oakland AthleticsS. Manaea -L | -1½ +105 | -145 | O 8½ -115 |
| 978 | Kansas City RoyalsM. Minor -L | +1½ -125 | +134 | U 8½ -105 |
