Aug 18 Wed 2021
| 3:45 PM | ||||
| 955 | New York MetsT. Megill -R | +144 | O 8½ -120 | |
| 956 | San Francisco GiantsA. Desclafani -R | -156 | U 8½ +100 |
| 4:05 PM | ||||
| 979 | Toronto Blue JaysJ. Berrios -R | -175 | O 9 -120 | |
| 980 | Washington NationalsJ. Gray -R | +161 | U 9 +100 |
| 7:05 PM | ||||
| 967 | Boston Red SoxN. Pivetta -R | +105 | O 10 -110 | |
| 968 | New York YankeesA. Heaney -L | -115 | U 10 -110 |
| 7:10 PM | ||||
| 957 | Atlanta BravesC. Morton -R | -191 | O 8 +105 | |
| 958 | Miami MarlinsJ. Luzardo -L | +175 | U 8 -125 |
| 7:10 PM | ||||
| 971 | Los Angeles AngelsS. Ohtani -R | -151 | O 8½ -120 | |
| 972 | Detroit TigersT. Skubal -L | +139 | U 8½ +100 |
| 7:45 PM | ||||
| 959 | Milwaukee BrewersF. Peralta -R | -115 | O 7 -120 | |
| 960 | St. Louis CardinalsJ. Flaherty -R | +105 | U 7 +100 |
| 8:05 PM | ||||
| 973 | Seattle MarinersM. Gonzales -L | -161 | O 8½ -120 | |
| 974 | Texas RangersM. Foltynewicz -R | +148 | U 8½ +100 |
| 8:10 PM | ||||
| 975 | Oakland AthleticsC. Irvin -L | +161 | O 9 -110 | |
| 976 | Chicago White SoxL. Lynn -R | -175 | U 9 -110 |
| 8:10 PM | ||||
| 977 | Houston AstrosZ. Greinke -R | -167 | O 10 -105 | |
| 978 | Kansas City RoyalsB. Singer -R | +154 | U 10 -115 |
