Sep 5 Sun 2021
| 12:05 PM | ||||
| 951 | New York MetsT. Walker -R | -1½ +110 | -151 | O 8½ -116 |
| 952 | Washington NationalsJ. Gray -R | +1½ -130 | +139 | U 8½ -104 |
| 12:05 PM | ||||
| 963 | Baltimore OriolesK. Akin -L | +1½ +130 | +249 | O 9½ -115 |
| 964 | New York YankeesC. Kluber -R | -1½ -150 | -280 | U 9½ -105 |
| 12:07 PM | ||||
| 965 | Oakland AthleticsC. Irvin -L | +1½ -117 | +170 | O 9 -110 |
| 966 | Toronto Blue JaysR. Ray -L | -1½ -103 | -185 | U 9 -110 |
| 12:10 PM | ||||
| 967 | Minnesota TwinsG. Jax -R | +1½ -112 | +179 | O 9 -110 |
| 968 | Tampa Bay RaysL. Patino -R | -1½ -108 | -195 | U 9 -110 |
| 12:10 PM | ||||
| 969 | Cleveland IndiansZ. Plesac -R | +1½ -135 | +148 | O 9½ -106 |
| 970 | Boston Red SoxN. Pivetta -R | -1½ +115 | -160 | U 9½ -114 |
| 12:10 PM | ||||
| 975 | Detroit TigersC. Mize -R | +1½ -110 | +188 | O 9 -104 |
| 976 | Cincinnati RedsL. Castillo -R | -1½ -110 | -205 | U 9 -116 |
| 1:10 PM | ||||
| 955 | St. Louis CardinalsJ. Lester -L | +1½ -105 | +204 | O 8 -105 |
| 956 | Milwaukee BrewersC. Burnes -R | -1½ -115 | -225 | U 8 -115 |
| 1:10 PM | ||||
| 971 | Chicago White SoxD. Cease -R | -1½ -115 | -170 | O 9 -120 |
| 972 | Kansas City RoyalsB. Singer -R | +1½ -105 | +157 | U 9 +100 |
| 2:10 PM | ||||
| 959 | Atlanta BravesC. Morton -R | -1½ -120 | -181 | O 11 -120 |
| 960 | Colorado RockiesA. Gomber -L | +1½ +100 | +166 | U 11 +100 |
| 3:10 PM | ||||
| 977 | Seattle MarinersC. Flexen -R | -1½ +105 | -142 | O 9 -105 |
| 978 | Arizona DiamondbacksT. Gilbert -L | +1½ -125 | +131 | U 9 -115 |
| 3:10 PM | ||||
| 979 | Houston AstrosL. Garcia -R | -1½ +130 | -115 | O 9 -104 |
| 980 | San Diego PadresC. Paddack -R | +1½ -150 | +105 | U 9 -116 |
