Sep 1 Wed 2021
| 1:05 PM | ||||
| 975 | Colorado RockiesK. Freeland -L | -130 | O 9 +100 | |
| 976 | Texas RangersK. Arihara -R | +120 | U 9 -120 |
| 2:40 PM | ||||
| 951 | San Diego PadresY. Darvish -R | -225 | O 8½ -115 | |
| 952 | Arizona DiamondbacksT. Widener -R | +204 | U 8½ -105 |
| 3:10 PM | ||||
| 963 | Houston AstrosJ. Odorizzi -R | -125 | O 8½ -125 | |
| 964 | Seattle MarinersL. Gilbert -R | +115 | U 8½ +105 |
| 6:05 PM | ||||
| 955 | Philadelphia PhilliesA. Nola -R | -177 | O 8½ -115 | |
| 956 | Washington NationalsP. Espino -R | +163 | U 8½ -105 |
| 6:07 PM | ||||
| 965 | New York YankeesG. Cole -R | -245 | O 8½ -115 | |
| 966 | Los Angeles AngelsP. Naughton -L | +220 | U 8½ -105 |
| 6:07 PM | ||||
| 967 | Baltimore OriolesM. Harvey -R | +228 | O 10 -115 | |
| 968 | Toronto Blue JaysS. Matz -L | -255 | U 10 -105 |
| 6:10 PM | ||||
| 957 | Miami MarlinsZ. Thompson -R | +166 | O 7½ -115 | |
| 958 | New York MetsC. Carrasco -R | -180 | U 7½ -105 |
| 6:10 PM | ||||
| 969 | Oakland AthleticsJ. Kaprielian -R | -158 | O 9½ -110 | |
| 970 | Detroit TigersW. Peralta -R | +146 | U 9½ -110 |
| 6:10 PM | ||||
| 971 | Boston Red SoxC. Sale -L | -141 | O 8 -110 | |
| 972 | Tampa Bay RaysD. Rasmussen -R | +130 | U 8 -110 |
| 7:10 PM | ||||
| 977 | Pittsburgh PiratesM. Keller -R | +275 | O 9 +100 | |
| 978 | Chicago White SoxC. Rodon -L | -310 | U 9 -120 |
| 8:45 PM | ||||
| 959 | Milwaukee BrewersB. Anderson -L | +130 | O 7½ -115 | |
| 960 | San Francisco GiantsK. Gausman -R | -140 | U 7½ -105 |
| 9:10 PM | ||||
| 961 | Atlanta BravesM. Fried -L | +176 | O 7½ -120 | |
| 962 | Los Angeles DodgersM. Scherzer -R | -192 | U 7½ +100 |
