May 19 Wed 2021
| 1:10 PM | ||||
| 965 | Chicago White SoxL. Giolito -R | -140 | O 8½ -120 | |
| 966 | Minnesota TwinsM. Shoemaker -R+1 Markets | +130 | U 8½ +100 |
| 4:10 PM | ||||
| 951 | Colorado RockiesC. Gonzalez -R | +1½ -105 | +212 | O 7½ -115 |
| 952 | San Diego PadresJ. Musgrove -R+1 Markets | -1½ -115 | -235 | U 7½ -105 |
| 6:40 PM | ||||
| 953 | San Francisco GiantsK. Gausman -R | -1½ +155 | -113 | O 8 -110 |
| 954 | Cincinnati RedsW. Miley -L+1 Markets | +1½ -175 | +103 | U 8 -110 |
| 7:05 PM | ||||
| 955 | Miami MarlinsT. Rogers -L | +1½ -195 | +114 | O 7½ -110 |
| 956 | Philadelphia PhilliesZ. Eflin -R+1 Markets | -1½ +170 | -124 | U 7½ -110 |
| 7:37 PM | ||||
| 969 | Boston Red SoxG. Richards -R | +1½ -170 | +110 | O 10½ +100 |
| 970 | Toronto Blue JaysR. Stripling -R+1 Markets | -1½ +150 | -120 | U 10½ -120 |
| 7:45 PM | ||||
| 961 | Pittsburgh PiratesT. Cahill -R | +1½ -120 | +184 | O 7 -125 |
| 962 | St. Louis CardinalsJ. Flaherty -R+1 Markets | -1½ +100 | -201 | U 7 +105 |
| 8:10 PM | ||||
| 979 | Milwaukee BrewersC. Burnes -R | -1½ +100 | -168 | O 7½ -110 |
| 980 | Kansas City RoyalsB. Keller -R+1 Markets | +1½ -120 | +155 | U 7½ -110 |
| 9:40 PM | ||||
| 975 | Houston AstrosZ. Greinke -R | +1½ -210 | -106 | O 8 -115 |
| 976 | Oakland AthleticsF. Montas -R+1 Markets | -1½ +180 | -104 | U 8 -105 |
| 10:10 PM | ||||
| 977 | Detroit TigersT. Skubal -L | +1½ -180 | +113 | O 8½ -110 |
| 978 | Seattle MarinersL. Gilbert -R+1 Markets | -1½ +160 | -123 | U 8½ -110 |
