Jun 8 Tue 2021
| 7:05 PM | ||||
| 951 | Los Angeles DodgersW. Buehler -R | -183 | O 7½ -105 | |
| 952 | Pittsburgh PiratesJ. Brubaker -R | +168 | U 7½ -115 |
| 7:05 PM | ||||
| 953 | Atlanta BravesD. Smyly -L | +140 | O 8½ -110 | |
| 954 | Philadelphia PhilliesA. Nola -R | -152 | U 8½ -110 |
| 7:05 PM | ||||
| 971 | New York MetsD. Peterson -L | -120 | O 9 -115 | |
| 972 | Baltimore OriolesB. Zimmermann -L | +110 | U 9 -105 |
| 7:10 PM | ||||
| 955 | Milwaukee BrewersA. Houser -R | +116 | O 8½ -110 | |
| 956 | Cincinnati RedsS. Gray -R | -126 | U 8½ -110 |
| 7:10 PM | ||||
| 957 | Colorado RockiesA. Senzatela -R | +148 | O 7½ -105 | |
| 958 | Miami MarlinsP. Lopez -R | -160 | U 7½ -115 |
| 7:10 PM | ||||
| 961 | Seattle MarinersM. Gonzales -L | +103 | O 8 -115 | |
| 962 | Detroit TigersM. Boyd -L | -113 | U 8 -105 |
| 7:10 PM | ||||
| 963 | Houston AstrosF. Valdez -L | -117 | O 9½ -115 | |
| 964 | Boston Red SoxM. Perez -L | +107 | U 9½ -105 |
| 7:10 PM | ||||
| 973 | Washington NationalsJ. Lester -L | +175 | O 7 -125 | |
| 974 | Tampa Bay RaysT. Glasnow -R | -190 | U 7 +105 |
| 8:05 PM | ||||
| 975 | San Francisco GiantsA. Wood -L | -135 | O 8½ -120 | |
| 976 | Texas RangersJ. Lyles -R | +125 | U 8½ +100 |
| 8:10 PM | ||||
| 965 | Toronto Blue JaysR. Ray -L | +130 | O 8½ +100 | |
| 966 | Chicago White SoxC. Rodon -L | -140 | U 8½ -120 |
| 8:10 PM | ||||
| 967 | New York YankeesJ. Montgomery -L | -108 | O 8½ -120 | |
| 968 | Minnesota TwinsM. Pineda -R | -102 | U 8½ +100 |
| 8:15 PM | ||||
| 977 | Cleveland IndiansS. Bieber -R | -165 | O 7½ -105 | |
| 978 | St. Louis CardinalsC. Martinez -R | +152 | U 7½ -115 |
| 9:38 PM | ||||
| 969 | Kansas City RoyalsK. Bubic -L | +131 | O 9 +110 | |
| 970 | Los Angeles AngelsA. Heaney -L+1 Markets | -142 | U 9 -130 |
| 9:40 PM | ||||
| 979 | Arizona DiamondbacksJ. Duplantier -R | +179 | O 8½ +105 | |
| 980 | Oakland AthleticsC. Bassitt -R | -195 | U 8½ -125 |
| 10:10 PM | ||||
| 959 | Chicago CubsZ. Davies -R | +148 | O 7½ -120 | |
| 960 | San Diego PadresD. Lamet -R+1 Markets | -161 | U 7½ +100 |
