Jun 17 Thu 2021
| 3:45 PM | ||||
| 901 | Arizona DiamondbacksC. Smith -L | +184 | O 7½ -115 | |
| 902 | San Francisco GiantsK. Gausman -R+1 Markets | -201 | U 7½ -105 |
| 7:10 PM | ||||
| 903 | Chicago CubsK. Hendricks -R | +115 | O 7½ -120 | |
| 904 | New York MetsM. Stroman -R+1 Markets | -125 | U 7½ +100 |
| 7:20 PM | ||||
| 905 | St. Louis CardinalsJ. Gant -R | +157 | O 9 +100 | |
| 906 | Atlanta BravesC. Morton -R | -171 | U 9 -120 |
| 8:10 PM | ||||
| 915 | Chicago White SoxD. Cease -R | +120 | O 9 -110 | |
| 916 | Houston AstrosJ. Urquidy -R | -130 | U 9 -110 |
| 8:40 PM | ||||
| 907 | Milwaukee BrewersB. Woodruff -R | -161 | O 10 +100 | |
| 908 | Colorado RockiesG. Marquez -R | +148 | U 10 -120 |
| 8:40 PM | ||||
| 909 | Cincinnati RedsW. Miley -L | +148 | O 7 -120 | |
| 910 | San Diego PadresJ. Musgrove -R | -161 | U 7 +100 |
| 9:38 PM | ||||
| 917 | Detroit TigersD. Manning -R | +192 | O 9 +100 | |
| 918 | Los Angeles AngelsS. Ohtani -R | -210 | U 9 -120 |
| 10:10 PM | ||||
| 919 | Tampa Bay RaysR. Hill -L | -171 | O 8 -120 | |
| 920 | Seattle MarinersJ. Dunn -R | +157 | U 8 +100 |
