Jun 3 Thu 2021
| 2:10 PM | ||||
| 915 | Boston Red SoxM. Perez -L | +127 | O 9 -120 | |
| 916 | Houston AstrosJ. Odorizzi -R+1 Markets | -137 | U 9 +100 |
| 8:10 PM | ||||
| 917 | Detroit TigersC. Mize -R | +181 | O 8 +100 | |
| 918 | Chicago White SoxL. Lynn -R | -197 | U 8 -120 |
| 8:15 PM | ||||
| 907 | Cincinnati RedsL. Castillo -R | +105 | O 8 -115 | |
| 908 | St. Louis CardinalsA. Wainwright -R | -115 | U 8 -105 |
| 9:38 PM | ||||
| 921 | Seattle MarinersJ. Sheffield -L | +134 | O 8½ +100 | |
| 922 | Los Angeles AngelsG. Canning -R | -145 | U 8½ -120 |
| 9:45 PM | ||||
| 909 | Chicago CubsZ. Davies -R | +115 | O 8 +100 | |
| 910 | San Francisco GiantsA. Desclafani -R | -125 | U 8 -120 |
| 10:10 PM | ||||
| 911 | New York MetsT. Walker -R | +153 | O 7 +100 | |
| 912 | San Diego PadresY. Darvish -R | -166 | U 7 -120 |
