Jun 5 Sun 2022
| 11:35 AM | ||||
| 915 | Detroit TigersR. Garcia -R | +1½ +120 | +249 | O 8½ -110 |
| 916 | New York YankeesJ. Montgomery -L | -1½ -140 | -280 | U 8½ -110 |
| 01:35 PM | ||||
| 901 | Arizona DiamondbacksZ. Gallen -R | -1½ +125 | -141 | O 7½ -125 |
| 902 | Pittsburgh PiratesZ. Thompson -R | +1½ -145 | +130 | U 7½ +105 |
| 01:35 PM | ||||
| 929 | Los Angeles AngelsP. Sandoval -L | +1½ -205 | -101 | O 8½ -115 |
| 930 | Philadelphia PhilliesK. Gibson -R | -1½ +175 | -109 | U 8½ -105 |
| 01:37 PM | ||||
| 919 | Minnesota TwinsD. Smeltzer -R | +1½ -130 | +175 | O 8 -115 |
| 920 | Toronto Blue JaysK. Gausman -R | -1½ +110 | -191 | U 8 -105 |
| 01:40 PM | ||||
| 903 | Washington NationalsP. Corbin -L | +1½ -140 | +150 | O 9½ -105 |
| 904 | Cincinnati RedsL. Castillo -R | -1½ +120 | -163 | U 9½ -115 |
| 02:10 PM | ||||
| 907 | San Diego PadresM. Clevinger -R | +1½ -190 | +115 | O 7½ -114 |
| 908 | Milwaukee BrewersE. Lauer -L | -1½ +165 | -125 | U 7½ -106 |
| 02:10 PM | ||||
| 923 | Houston AstrosF. Valdez -L | -1½ -130 | -210 | O 9 -120 |
| 924 | Kansas City RoyalsJ. Heasley -R | +1½ +110 | +192 | U 9 +100 |
| 02:35 PM | ||||
| 925 | Seattle MarinersG. Kirby -R | +1½ -190 | +104 | O 8 -105 |
| 926 | Texas RangersM. Perez -L | -1½ +165 | -114 | U 8 -115 |
| 03:10 PM | ||||
| 911 | Atlanta BravesC. Morton -R | -1½ -110 | -147 | O 12 +100 |
| 912 | Colorado RockiesR. Feltner -R | +1½ -110 | +136 | U 12 -120 |
| 04:07 PM | ||||
| 927 | Boston Red SoxR. Hill -L | +1½ -210 | +102 | O 7½ +100 |
| 928 | Oakland AthleticsF. Montas -R | -1½ +180 | -112 | U 7½ -120 |
| 04:10 PM | ||||
| 913 | New York MetsT. Williams -R | +1½ -130 | +170 | O 8½ -110 |
| 914 | Los Angeles DodgersJ. Urias -L | -1½ +110 | -185 | U 8½ -110 |
