Sep 26 Sun 2021
| 11:10 AM | ||||
| 915 | Kansas City RoyalsK. Bubic -L | +1½ -190 | -105 | O 9 -105 |
| 916 | Detroit TigersW. Peralta -R+1 Markets | -1½ +165 | -105 | U 9 -115 |
| 12:05 PM | ||||
| 917 | Texas RangersD. Dunning -R | +1½ -165 | +114 | O 8½ -115 |
| 918 | Baltimore OriolesJ. Means -L | -1½ +145 | -124 | U 8½ -105 |
| 12:10 PM | ||||
| 903 | Washington NationalsJ. Rogers -L | +1½ -125 | +157 | O 9½ +100 |
| 904 | Cincinnati RedsT. Mahle -R | -1½ +105 | -171 | U 9½ -120 |
| 12:10 PM | ||||
| 919 | Chicago White SoxL. Giolito -R | -1½ -110 | -161 | O 8 -110 |
| 920 | Cleveland IndiansT. McKenzie -R | +1½ -110 | +148 | U 8 -110 |
| 1:10 PM | ||||
| 921 | Toronto Blue JaysA. Manoah -R | -1½ -120 | -181 | O 9 -120 |
| 922 | Minnesota TwinsG. Jax -R | +1½ +100 | +166 | U 9 +100 |
| 2:10 PM | ||||
| 909 | San Francisco GiantsK. Gausman -R | -1½ -115 | -167 | O 11½ +100 |
| 910 | Colorado RockiesA. Senzatela -R | +1½ -105 | +154 | U 11½ -120 |
| 3:07 PM | ||||
| 923 | Seattle MarinersM. Gonzales -L | +1½ -155 | +129 | O 8½ -105 |
| 924 | Los Angeles AngelsS. Ohtani -R | -1½ +135 | -139 | U 8½ -115 |
| 3:07 PM | ||||
| 925 | Houston AstrosJ. Odorizzi -R | -1½ +125 | -112 | O 9 -111 |
| 926 | Oakland AthleticsP. Blackburn -R | +1½ -145 | +102 | U 9 -109 |
| 3:10 PM | ||||
| 911 | Los Angeles DodgersJ. Urias -L | -1½ -160 | -265 | O 9 -110 |
| 912 | Arizona DiamondbacksH. Mejia -R | +1½ +140 | +237 | U 9 -110 |
| 6:08 PM | ||||
| 927 | New York YankeesJ. Montgomery -L | +1½ -175 | +107 | O 10 -110 |
| 928 | Boston Red SoxE. Rodriguez -L+1 Markets | -1½ +155 | -117 | U 10 -110 |
