Sep 20 Mon 2021
| 5:40 PM | ||||
| 901 | Pittsburgh PiratesD. Peters -L | +1½ -125 | +158 | O 9 -122 |
| 902 | Cincinnati RedsV. Gutierrez -R | -1½ +105 | -172 | U 9 +102 |
| 5:40 PM | ||||
| 903 | Washington NationalsE. Fedde -R | -1½ +145 | -112 | O 8½ -105 |
| 904 | Miami MarlinsJ. Luzardo -L | +1½ -165 | +102 | U 8½ -115 |
| 5:40 PM | ||||
| 911 | Chicago White SoxC. Rodon -L | -1½ -135 | -212 | O 9 -105 |
| 912 | Detroit TigersM. Manning -R | +1½ +115 | +193 | U 9 -115 |
| 6:05 PM | ||||
| 913 | Texas RangersA. Alexy -R | +1½ +113 | +221 | O 9½ -110 |
| 914 | New York YankeesN. Cortes -L | -1½ -133 | -247 | U 9½ -110 |
| 6:05 PM | ||||
| 923 | Baltimore OriolesJ. Means -L | +1½ -125 | +170 | O 8 -120 |
| 924 | Philadelphia PhilliesR. Suarez -L | -1½ +105 | -185 | U 8 +100 |
| 6:10 PM | ||||
| 915 | Toronto Blue JaysR. Ray -L | -1½ +125 | -123 | O 8½ -102 |
| 916 | Tampa Bay RaysS. Baz -R | +1½ -145 | +113 | U 8½ -118 |
| 6:40 PM | ||||
| 905 | St. Louis CardinalsJ. Woodford -R | +1½ -120 | +180 | O 8 -115 |
| 906 | Milwaukee BrewersF. Peralta -R | -1½ +100 | -196 | U 8 -105 |
| 8:38 PM | ||||
| 919 | Houston AstrosF. Valdez -L | -1½ -135 | -210 | O 9 -110 |
| 920 | Los Angeles AngelsJ. Barria -R | +1½ +115 | +192 | U 9 -110 |
| 8:40 PM | ||||
| 921 | Seattle MarinersT. Anderson -L | +1½ -145 | +140 | O 8½ +100 |
| 922 | Oakland AthleticsS. Manaea -L | -1½ +125 | -152 | U 8½ -120 |
