Sep 16 Fri 2022
| 06:10 PM | ||||
| 905 | Pittsburgh PiratesM. Keller -R | +1½ -105 | +224 | O 7½ -115 |
| 906 | New York MetsT. Walker -R | -1½ -115 | -250 | U 7½ -105 |
| 06:10 PM | ||||
| 919 | Texas RangersM. Perez -L | +1½ -170 | +130 | O 7½ +110 |
| 920 | Tampa Bay RaysC. Kluber -R | -1½ +150 | -141 | U 7½ -130 |
| 06:10 PM | ||||
| 921 | Kansas City RoyalsJ. Heasley -R | +1½ -120 | +184 | O 9½ -105 |
| 922 | Boston Red SoxM. Wacha -R | -1½ +100 | -200 | U 9½ -115 |
| 06:10 PM | ||||
| 923 | Chicago White SoxL. Giolito -R | -1½ +115 | -144 | O 7½ -120 |
| 924 | Detroit TigersM. Manning -R | +1½ -135 | +133 | U 7½ +100 |
| 06:20 PM | ||||
| 907 | Philadelphia PhilliesR. Suarez -L | +1½ -130 | +162 | O 7½ -115 |
| 908 | Atlanta BravesM. Fried -L | -1½ +110 | -176 | U 7½ -105 |
| 07:10 PM | ||||
| 925 | Oakland AthleticsA. Martinez -R | +1½ +140 | +301 | O 7½ -105 |
| 926 | Houston AstrosJ. Verlander -R | -1½ -155 | -340 | U 7½ -115 |
| 07:10 PM | ||||
| 929 | New York YankeesF. Montas -R | -1½ +130 | -120 | O 8 -115 |
| 930 | Milwaukee BrewersA. Houser -R | +1½ -150 | +110 | U 8 -105 |
| 08:38 PM | ||||
| 927 | Seattle MarinersR. Ray -L | -1½ +105 | -151 | O 8 -120 |
| 928 | Los Angeles AngelsM. Lorenzen -R | +1½ -125 | +139 | U 8 +100 |
| 08:40 PM | ||||
| 911 | San Diego PadresB. Snell -L | -1½ -110 | -175 | O 8½ -115 |
| 912 | Arizona DiamondbacksM. Bumgarner -L | +1½ -110 | +161 | U 8½ -105 |
| 09:15 PM | ||||
| 913 | Los Angeles DodgersD. May -R | -1½ +110 | -155 | O 7½ -105 |
| 914 | San Francisco GiantsL. Webb -R | +1½ -130 | +143 | U 7½ -115 |
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