Apr 8 Fri 2022
| 12:05 PM | ||||
| 931 | Boston Red SoxN. Eovaldi -R | +1½ -140 | +148 | O 8 -115 |
| 932 | New York Yankees G. Cole -R+1 Markets | -1½ +120 | -160 | U 8 -105 |
| 12:10 PM | ||||
| 921 | Chicago White SoxL. Giolito -R | -1½ +135 | -132 | O 8 +100 |
| 922 | Detroit TigersE. Rodriguez -L+1 Markets | +1½ -155 | +122 | U 8 -120 |
| 02:05 PM | ||||
| 929 | Oakland AthleticsF. Montas -R | +1½ -125 | +166 | O 8 +100 |
| 930 | Philadelphia PhilliesA. Nola -R+1 Markets | -1½ +105 | -181 | U 8 -120 |
| 02:10 PM | ||||
| 923 | Baltimore OriolesJ. Means -L | +1½ -140 | +164 | O 7½ -115 |
| 924 | Tampa Bay RaysS. McClanahan -L+1 Markets | -1½ +120 | -178 | U 7½ -105 |
| 03:10 PM | ||||
| 911 | Los Angeles DodgersW. Buehler -R | -1½ -135 | -200 | O 11½ -105 |
| 912 | Colorado RockiesK. Freeland -L+1 Markets | +1½ +115 | +184 | U 11½ -115 |
| 03:10 PM | ||||
| 933 | Seattle MarinersR. Ray -L | +1½ -205 | +107 | O 8 +100 |
| 934 | Minnesota Twins J. Ryan -R+1 Markets | -1½ +175 | -117 | U 8 -120 |
| 03:35 PM | ||||
| 913 | Miami MarlinsS. Alcantara -R | +1½ -175 | +128 | O 7½ -101 |
| 914 | San Francisco GiantsL. Webb -R+1 Markets | -1½ +155 | -138 | U 7½ -119 |
| 06:05 PM | ||||
| 915 | New York MetsM. Scherzer -R | -1½ -105 | -165 | O 8½ -124 |
| 916 | Washington NationalsJ. Gray -R+1 Markets | +1½ -115 | +152 | U 8½ +104 |
| 06:07 PM | ||||
| 925 | Texas RangersJ. Gray -R | +1½ -130 | +146 | O 9½ +110 |
| 926 | Toronto Blue JaysJ. Berrios -R+1 Markets | -1½ +110 | -158 | U 9½ -130 |
| 06:20 PM | ||||
| 917 | Cincinnati RedsR. Sanmartin -L | +1½ -123 | +157 | O 9 +107 |
| 918 | Atlanta BravesC. Morton -R+1 Markets | -1½ +103 | -170 | U 9 -127 |
| 08:40 PM | ||||
| 919 | San Diego PadresS. Manaea -L | -1½ +105 | -132 | O 9½ +105 |
| 920 | Arizona DiamondbacksM. Kelly -R+1 Markets | +1½ -125 | +122 | U 9½ -125 |
