Jun 6 Sun 2021
| 1:05 PM | ||||
| 953 | Miami MarlinsS. Alcantara -R | -1½ +121 | -135 | O 8 +100 |
| 954 | Pittsburgh PiratesC. Kuhl -R+1 Markets | +1½ -141 | +125 | U 8 -120 |
| 1:07 PM | ||||
| 967 | Houston AstrosL. Garcia -R | +103 | O 10 -105 | |
| 968 | Toronto Blue JaysS. Matz -L+1 Markets | -113 | U 10 -115 |
| 1:20 PM | ||||
| 955 | Los Angeles DodgersT. Bauer -R | -1½ +119 | -135 | O 8 -115 |
| 956 | Atlanta BravesM. Fried -L+1 Markets | +1½ -139 | +125 | U 8 -105 |
| 2:10 PM | ||||
| 957 | Arizona DiamondbacksC. Smith -L | +204 | O 7½ -115 | |
| 958 | Milwaukee BrewersC. Burnes -R+1 Markets | -225 | U 7½ -105 |
| 2:10 PM | ||||
| 971 | Detroit TigersJ. Urena -R | +188 | O 8½ -115 | |
| 972 | Chicago White SoxD. Cease -R+1 Markets | -205 | U 8½ -105 |
| 2:15 PM | ||||
| 959 | Cincinnati RedsW. Miley -L | +110 | O 9 +105 | |
| 960 | St. Louis CardinalsJ. Gant -R+1 Markets | -120 | U 9 -125 |
| 3:10 PM | ||||
| 979 | Oakland AthleticsJ. Kaprielian -R | -107 | O 11½ -105 | |
| 980 | Colorado RockiesG. Marquez -R+1 Markets | -103 | U 11½ -115 |
| 4:05 PM | ||||
| 961 | Chicago CubsK. Hendricks -R | -110 | O 8 -120 | |
| 962 | San Francisco GiantsJ. Cueto -R+1 Markets | +100 | U 8 +100 |
| 4:10 PM | ||||
| 963 | New York MetsM. Stroman -R | +120 | O 8 -105 | |
| 964 | San Diego PadresC. Paddack -R+1 Markets | -130 | U 8 -115 |
| 7:08 PM | ||||
| 977 | Boston Red SoxG. Richards -R | +134 | O 9½ +105 | |
| 978 | New York YankeesD. German -R+1 Markets | -145 | U 9½ -125 |
