Jun 3 Fri 2022
| 02:20 PM | ||||
| 901 | St. Louis CardinalsM. Mikolas -R | -103 | O 8 -110 | |
| 902 | Chicago CubsM. Stroman -R | -107 | U 8 -110 |
| 06:40 PM | ||||
| 903 | San Francisco GiantsA. Cobb -R | -1½ +105 | -146 | O 7½ -112 |
| 904 | Miami MarlinsE. Hernandez -R | +1½ -125 | +135 | U 7½ -108 |
| 06:40 PM | ||||
| 905 | Washington NationalsJ. Gray -R | +1½ -165 | +115 | O 9½ -108 |
| 906 | Cincinnati RedsM. Minor -L | -1½ +145 | -125 | U 9½ -112 |
| 07:05 PM | ||||
| 907 | Arizona DiamondbacksM. Kelly -R | +1½ -205 | -102 | O 7½ -113 |
| 908 | Pittsburgh PiratesJ. Brubaker -R | -1½ +175 | -108 | U 7½ -107 |
| 07:05 PM | ||||
| 917 | Detroit TigersElvin Rodriguez -R | +287 | O 8 -105 | |
| 918 | New York YankeesG. Cole -R | -325 | U 8 -115 |
| 07:10 PM | ||||
| 921 | Chicago White SoxV. Velasquez -R | +1½ -115 | +179 | O 7 -120 |
| 922 | Tampa Bay RaysS. McClanahan -L | -1½ -105 | -195 | U 7 +100 |
| 08:10 PM | ||||
| 909 | San Diego PadresJ. Musgrove -R | +1½ -167 | +138 | O 6½ -122 |
| 910 | Milwaukee BrewersC. Burnes -R | -1½ +147 | -149 | U 6½ +102 |
| 08:10 PM | ||||
| 925 | Houston AstrosJ. Urquidy -R | -1½ +125 | -122 | O 8½ -115 |
| 926 | Kansas City RoyalsB. Singer -R | +1½ -145 | +112 | U 8½ -105 |
| 08:40 PM | ||||
| 911 | Atlanta BravesM. Fried -L | -1½ -115 | -172 | O 11½ +105 |
| 912 | Colorado RockiesC. Kuhl -R | +1½ -105 | +158 | U 11½ -125 |
| 09:40 PM | ||||
| 927 | Boston Red SoxN. Eovaldi -R | -1½ +105 | -155 | O 7 -125 |
| 928 | Oakland AthleticsJ. Kaprielian -R | +1½ -125 | +143 | U 7 +105 |
| 10:10 PM | ||||
| 913 | New York MetsC. Bassitt -R | +1½ -145 | +143 | O 8½ -115 |
| 914 | Los Angeles DodgersT. Anderson -L | -1½ +125 | -155 | U 8½ -105 |
