Nov 9 Tue 2021
Nov 10 Wed 2021
Nov 11 Thu 2021
Nov 12 Fri 2021
Nov 13 Sat 2021
| 06:00 PM | ||||
| 101 | Buffalo | +7 -110 | O 57 -110 | |
| 102 | Miami Ohio | -7 -110 | U 57 -110 |
| 06:00 PM | ||||
| 105 | Akron | +25 -110 | O 62 -110 | |
| 106 | Western Michigan | -25 -110 | U 62 -110 |
| 07:00 PM | ||||
| 103 | Ohio | +7½ -110 | O 61 -110 | |
| 104 | Eastern Michigan | -7½ -110 | U 61 -110 |
| 06:00 PM | ||||
| 107 | Toledo | -9½ -110 | O 52½ -105 | |
| 108 | Bowling Green | +9½ -110 | U 52½ -115 |
| 06:00 PM | ||||
| 111 | Ball State | -2½ -102 | O 61½ -110 | |
| 112 | Northern Illinois | +2½ -118 | U 61½ -110 |
| 07:00 PM | ||||
| 109 | Kent State | +3 -110 | O 71 -110 | |
| 110 | Central Michigan | -3 -110 | U 71 -110 |
| 06:30 PM | ||||
| 115 | North Carolina | +6 -110 | O 76 -110 | |
| 116 | Pittsburgh | -6 -110 | U 76 -110 |
| 05:00 PM | ||||
| 117 | Cincinnati | -23½ -110 | O 59 -110 | |
| 118 | South Florida | +23½ -110 | U 59 -110 |
| 08:00 PM | ||||
| 119 | Wyoming | +14 -105 | O 47 -110 | |
| 120 | Boise State | -14 -115 | U 47 -110 |
| 11:00 AM | ||||
| 121 | West Virginia | +5½ -105 | O 47 -110 | |
| 122 | Kansas State | -5½ -115 | U 47 -110 |
| 11:00 AM | ||||
| 125 | Connecticut | +40 -110 | O 49½ -110 | |
| 126 | Clemson | -40 -110 | U 49½ -110 |
| 11:00 AM | ||||
| 133 | Michigan | pk -110 | O 47 -110 | |
| 134 | Penn State | pk -110 | U 47 -110 |
| 11:00 AM | ||||
| 141 | Syracuse | +3 -103 | O 56 -110 | |
| 142 | Louisville | -3 -117 | U 56 -110 |
| 11:00 AM | ||||
| 153 | Northwestern | +23 -105 | O 42 -105 | |
| 154 | Wisconsin | -23 -115 | U 42 -115 |
| 01:00 PM | ||||
| 123 | Georgia State | +10½ -115 | O 53 -105 | |
| 124 | Coastal Carolina | -10½ -105 | U 53 -115 |
| 02:30 PM | ||||
| 129 | Duke | +11 -110 | O 48½ -110 | |
| 130 | Virginia Tech | -11 -110 | U 48½ -110 |
| 02:30 PM | ||||
| 131 | Boston College | +2½ -115 | O 51½ -115 | |
| 132 | Georgia Tech | -2½ -105 | U 51½ -105 |
| 03:00 PM | ||||
| 139 | Maryland | +13 -110 | O 63 -105 | |
| 140 | Michigan State | -13 -110 | U 63 -115 |
| 06:30 PM | ||||
| 147 | NC State | +2½ -115 | O 66½ -110 | |
| 148 | Wake Forest | -2½ -105 | U 66½ -110 |
| 06:30 PM | ||||
| 151 | Notre Dame | -5 -110 | O 64½ -110 | |
| 152 | Virginia | +5 -110 | U 64½ -110 |
| 07:00 PM | ||||
| 143 | TCU | +13½ -107 | O 54½ -110 | |
| 144 | Oklahoma State | -13½ -113 | U 54½ -110 |