Sep 25 Sat 2021
| 3:05 PM | ||||
| 953 | Pittsburgh PiratesW. Crowe -R | +1½ +100 | +218 | O 9 +100 |
| 954 | Philadelphia PhilliesR. Suarez -L | -1½ -120 | -243 | U 9 -120 |
| 3:07 PM | ||||
| 965 | Houston AstrosF. Valdez -L | -102 | O 8½ +100 | |
| 966 | Oakland AthleticsS. Manaea -L | -108 | U 8½ -120 |
| 3:10 PM | ||||
| 967 | New York YankeesN. Cortes -L | +101 | O 10½ -105 | |
| 968 | Boston Red SoxN. Pivetta -R | -111 | U 10½ -115 |
| 5:10 PM | ||||
| 969 | Kansas City RoyalsJ. Heasley -R | +121 | O 9 -115 | |
| 970 | Detroit TigersT. Skubal -L | -131 | U 9 -105 |
| 5:10 PM | ||||
| 979 | Miami MarlinsS. Alcantara -R | +189 | O 7½ -110 | |
| 980 | Tampa Bay RaysS. McClanahan -L | -207 | U 7½ -110 |
| 6:05 PM | ||||
| 971 | Texas RangersJ. Lyles -R | +130 | O 8½ -120 | |
| 972 | Baltimore OriolesJ. Means -L | -141 | U 8½ +100 |
| 6:10 PM | ||||
| 955 | Washington NationalsE. Fedde -R | +1½ -135 | +150 | O 9½ -105 |
| 956 | Cincinnati RedsV. Gutierrez -R | -1½ +115 | -163 | U 9½ -115 |
| 6:15 PM | ||||
| 975 | Chicago White SoxL. Lynn -R | -174 | O 8½ -120 | |
| 976 | Cleveland IndiansE. Morgan -R | +160 | U 8½ +100 |
| 7:10 PM | ||||
| 961 | San Francisco GiantsA. Desclafani -R | -1½ -105 | -150 | O 11½ -120 |
| 962 | Colorado RockiesJ. Gray -R | +1½ -115 | +139 | U 11½ +100 |
| 7:10 PM | ||||
| 963 | Los Angeles DodgersC. Kershaw -L | -1½ -145 | -232 | O 9 +100 |
| 964 | Arizona DiamondbacksZ. Gallen -R | +1½ +125 | +209 | U 9 -120 |
