Sep 18 Sat 2021
| 12:05 PM | ||||
| 915 | Cleveland IndiansA. Civale -R | +1½ -115 | +167 | O 9½ -110 |
| 916 | New York YankeesL. Gil -R | -1½ -105 | -182 | U 9½ -110 |
| 12:10 PM | ||||
| 917 | Baltimore OriolesZ. Lowther -L | +1½ +120 | +225 | O 10½ -110 |
| 918 | Boston Red SoxN. Pivetta -R | -1½ -140 | -251 | U 10½ -110 |
| 1:10 PM | ||||
| 901 | Los Angeles DodgersM. Scherzer -R | -1½ -114 | -181 | O 8 -120 |
| 902 | Cincinnati RedsS. Gray -R | +1½ -106 | +166 | U 8 +100 |
| 2:07 PM | ||||
| 919 | Minnesota TwinsB. Ober -R | +1½ -125 | +154 | O 9½ -110 |
| 920 | Toronto Blue JaysS. Matz -L | -1½ +105 | -167 | U 9½ -110 |
| 3:05 PM | ||||
| 903 | Colorado RockiesK. Freeland -L | +1½ -190 | +106 | O 9 -105 |
| 904 | Washington NationalsP. Corbin -L | -1½ +165 | -116 | U 9 -115 |
| 3:10 PM | ||||
| 921 | Detroit TigersT. Skubal -L | +1½ -120 | +166 | O 8½ -120 |
| 922 | Tampa Bay RaysR. Yarbrough -L | -1½ +100 | -181 | U 8½ +100 |
| 5:10 PM | ||||
| 905 | Pittsburgh PiratesB. Wilson -R | +1½ -170 | +121 | O 8 -115 |
| 906 | Miami MarlinsE. Cabrera -R | -1½ +150 | -131 | U 8 -105 |
| 6:05 PM | ||||
| 923 | Chicago White SoxL. Lynn -R | -1½ -135 | -215 | O 9 +100 |
| 924 | Texas RangersS. Howard -R | +1½ +115 | +196 | U 9 -120 |
| 6:10 PM | ||||
| 925 | Seattle MarinersY. Kikuchi -L | -1½ +125 | -120 | O 9 -105 |
| 926 | Kansas City RoyalsK. Bubic -L | +1½ -145 | +110 | U 9 -115 |
| 6:10 PM | ||||
| 929 | Arizona DiamondbacksH. Castellanos -R | +1½ +115 | +237 | O 9 -110 |
| 930 | Houston AstrosL. McCullers Jr. -R | -1½ -135 | -265 | U 9 -110 |
| 6:15 PM | ||||
| 907 | Philadelphia PhilliesA. Nola -R | -1½ +145 | -116 | O 8 +100 |
| 908 | New York MetsC. Carrasco -R | +1½ -165 | +106 | U 8 -120 |
| 6:15 PM | ||||
| 909 | Chicago CubsJ. Steele -L | +1½ +110 | +241 | O 8 -115 |
| 910 | Milwaukee BrewersC. Burnes -R | -1½ -130 | -270 | U 8 -105 |
| 6:15 PM | ||||
| 911 | San Diego PadresY. Darvish -R | +1½ -205 | +101 | O 8 -105 |
| 912 | St. Louis CardinalsA. Wainwright -R | -1½ +175 | -111 | U 8 -115 |
| 8:07 PM | ||||
| 927 | Oakland AthleticsD. Jefferies -R | -1½ +115 | -131 | O 9 -120 |
| 928 | Los Angeles AngelsJ. Suarez -L | +1½ -135 | +121 | U 9 +100 |
