Jul 22 Fri 2022
| 06:40 PM | ||||
| 901 | St. Louis CardinalsA. Wainwright -R | -1½ +105 | -145 | O 10 -105 |
| 902 | Cincinnati RedsG. Ashcraft -R | +1½ -125 | +134 | U 10 -115 |
| 07:05 PM | ||||
| 905 | Chicago CubsJ. Steele -L | +1½ -170 | +117 | O 9 -105 |
| 906 | Philadelphia PhilliesK. Gibson -R | -1½ +150 | -127 | U 9 -115 |
| 07:05 PM | ||||
| 915 | New York YankeesJ. Taillon -R | -1½ -105 | -154 | O 9 +105 |
| 916 | Baltimore OriolesT. Wells -R | +1½ -115 | +142 | U 9 -125 |
| 07:10 PM | ||||
| 907 | San Diego PadresY. Darvish -R | +1½ -140 | +161 | O 6½ -120 |
| 908 | New York MetsM. Scherzer -R | -1½ +120 | -175 | U 6½ +100 |
| 07:20 PM | ||||
| 927 | Los Angeles AngelsS. Ohtani -R | +1½ -170 | +132 | O 7 -120 |
| 928 | Atlanta BravesC. Morton -R | -1½ +150 | -143 | U 7 +100 |
| 08:10 PM | ||||
| 909 | Colorado RockiesA. Senzatela -R | +1½ -103 | +226 | O 7½ +100 |
| 910 | Milwaukee BrewersC. Burnes -R | -1½ -117 | -253 | U 7½ -120 |
| 08:10 PM | ||||
| 919 | Cleveland GuardiansC. Quantrill -R | +1½ -150 | +135 | O 8 -120 |
| 920 | Chicago White SoxL. Giolito -R | -1½ +130 | -146 | U 8 +100 |
| 09:40 PM | ||||
| 923 | Texas RangersS. Howard -R | -1½ +150 | -110 | O 7 -115 |
| 924 | Oakland AthleticsC. Irvin -L | +1½ -170 | +100 | U 7 -105 |
| 10:10 PM | ||||
| 913 | San Francisco GiantsL. Webb -R | +1½ -170 | +127 | O 7½ -125 |
| 914 | Los Angeles DodgersT. Anderson -L | -1½ +150 | -137 | U 7½ +105 |
| 10:10 PM | ||||
| 925 | Houston AstrosJ. Urquidy -R | -1½ +140 | -112 | O 8 -115 |
| 926 | Seattle MarinersM. Gonzales -L | +1½ -160 | +102 | U 8 -105 |
