Sep 29 Wed 2021
| 2:10 PM | ||||
| 951 | Washington NationalsP. Espino -R | -1½ +127 | -103 | O 12½ -102 |
| 952 | Colorado RockiesP. Lambert -R | +1½ -147 | -107 | U 12½ -118 |
| 6:05 PM | ||||
| 965 | Boston Red SoxN. Eovaldi -R | -1½ -155 | -240 | O 9½ -105 |
| 966 | Baltimore OriolesZ. Lowther -L | +1½ +135 | +216 | U 9½ -115 |
| 6:07 PM | ||||
| 967 | New York YankeesG. Cole -R | -1½ +140 | -110 | O 8½ -105 |
| 968 | Toronto Blue JaysJ. Berrios -R | +1½ -160 | +100 | U 8½ -115 |
| 6:10 PM | ||||
| 955 | Miami MarlinsE. Hernandez -R | +1½ -145 | +155 | O 7½ +102 |
| 956 | New York MetsT. Walker -R | -1½ +125 | -168 | U 7½ -122 |
| 6:20 PM | ||||
| 957 | Philadelphia PhilliesA. Nola -R | +1½ -165 | +125 | O 8 -105 |
| 958 | Atlanta BravesM. Fried -L | -1½ +145 | -135 | U 8 -115 |
| 6:40 PM | ||||
| 969 | Detroit TigersC. Mize -R | +1½ -130 | +148 | O 9 -113 |
| 970 | Minnesota TwinsM. Pineda -R | -1½ +110 | -160 | U 9 -107 |
| 7:05 PM | ||||
| 971 | Los Angeles AngelsJ. Junk -R | +1½ -180 | +110 | O 9 -107 |
| 972 | Texas RangersT. Hearn -L | -1½ +160 | -120 | U 9 -113 |
| 7:10 PM | ||||
| 973 | Cleveland IndiansZ. Plesac -R | -1½ +137 | -115 | O 9 -105 |
| 974 | Kansas City RoyalsD. Lynch -L | +1½ -157 | +105 | U 9 -115 |
| 7:10 PM | ||||
| 979 | Cincinnati RedsS. Gray -R | +1½ -130 | +155 | O 8½ +100 |
| 980 | Chicago White SoxC. Rodon -L | -1½ +110 | -168 | U 8½ -120 |
| 8:45 PM | ||||
| 961 | Arizona DiamondbacksM. Kelly -R | +1½ +110 | +233 | O 8 -117 |
| 962 | San Francisco GiantsA. Wood -L | -1½ -130 | -260 | U 8 -103 |
| 9:10 PM | ||||
| 977 | Oakland AthleticsF. Montas -R | -1½ +141 | -111 | O 8 +105 |
| 978 | Seattle MarinersL. Gilbert -R | +1½ -161 | +101 | U 8 -125 |