May 31 Tue 2022
| 01:10 PM | ||||
| 965 | Minnesota Twins - Game #1D. Smeltzer -L | -1½ +110 | -141 | O 8½ -125 |
| 966 | Detroit Tigers - Game #1R. Garcia -R | +1½ -130 | +130 | U 8½ +105 |
| 06:10 PM | ||||
| 967 | Kansas City RoyalsD. Lynch -L | +1½ -150 | +129 | O 9½ -110 |
| 968 | Cleveland GuardiansC. Quantrill -R | -1½ +130 | -139 | U 9½ -110 |
| 06:45 PM | ||||
| 951 | San Francisco GiantsJ. Junis -R | +1½ -165 | +114 | O 9 -125 |
| 952 | Philadelphia PhilliesR. Suarez -L | -1½ +145 | -124 | U 9 +105 |
| 07:05 PM | ||||
| 971 | Los Angeles AngelsN. Syndergaard -R | +1½ -168 | +118 | O 8½ -125 |
| 972 | New York YankeesJ. Montgomery -L | -1½ +148 | -128 | U 8½ +105 |
| 07:07 PM | ||||
| 973 | Chicago White SoxL. Giolito -R | +1½ -145 | +153 | O 7½ -126 |
| 974 | Toronto Blue JaysK. Gausman -R | -1½ +125 | -166 | U 7½ +106 |
| 07:10 PM | ||||
| 953 | Washington NationalsP. Corbin -L | +1½ -140 | +157 | O 9 -120 |
| 954 | New York MetsT. Williams -R | -1½ +120 | -171 | U 9 +100 |
| 07:10 PM | ||||
| 981 | Cincinnati RedsL. Castillo -R | +1½ -160 | +130 | O 8½ -120 |
| 982 | Boston Red SoxM. Wacha -R | -1½ +140 | -141 | U 8½ +100 |
| 07:45 PM | ||||
| 955 | San Diego PadresB. Snell -L | +1½ -180 | +114 | O 8½ -115 |
| 956 | St. Louis CardinalsA. Wainwright -R | -1½ +160 | -124 | U 8½ -105 |
| 09:40 PM | ||||
| 961 | Atlanta BravesC. Morton -R | -1½ -110 | -161 | O 9 -115 |
| 962 | Arizona DiamondbacksH. Castellanos -R | +1½ -110 | +148 | U 9 -105 |
| 09:40 PM | ||||
| 979 | Houston AstrosC. Javier -R | -1½ +130 | -126 | O 7 -120 |
| 980 | Oakland AthleticsF. Montas -R | +1½ -150 | +116 | U 7 +100 |