May 3 Tue 2022
| 05:10 PM | ||||
| 973 | San Diego PadresM. Clevinger -R | -1½ +125 | -138 | O 7½ -120 |
| 974 | Cleveland GuardiansZ. Plesac -R+1 Markets | +1½ -145 | +128 | U 7½ +100 |
| 05:45 PM | ||||
| 975 | Texas RangersJ. Gray -R | +1½ -140 | +148 | O 8½ -110 |
| 976 | Philadelphia PhilliesR. Suarez -L | -1½ +120 | -160 | U 8½ -110 |
| 06:05 PM | ||||
| 963 | Minnesota TwinsJ. Ryan -R | -1½ +100 | -160 | O 7 -105 |
| 964 | Baltimore OriolesB. Zimmermann -L | +1½ -120 | +148 | U 7 -115 |
| 06:07 PM | ||||
| 965 | New York YankeesJ. Taillon -R | +1½ -185 | +125 | O 8 +100 |
| 966 | Toronto Blue JaysA. Manoah -R | -1½ +165 | -135 | U 8 -120 |
| 06:10 PM | ||||
| 967 | Los Angeles AngelsN. Syndergaard -R | -1½ +130 | -120 | O 8½ -105 |
| 968 | Boston Red SoxM. Wacha -R | +1½ -150 | +110 | U 8½ -115 |
| 06:10 PM | ||||
| 977 | Pittsburgh PiratesB. Wilson -R | +1½ -160 | +126 | O 8 -120 |
| 978 | Detroit TigersM. Pineda -R | -1½ +140 | -136 | U 8 +100 |
| 07:10 PM | ||||
| 969 | Seattle MarinersC. Flexen -R | +1½ -150 | +135 | O 8½ -110 |
| 970 | Houston AstrosC. Javier -R | -1½ +130 | -146 | U 8½ -110 |
| 07:10 PM | ||||
| 981 | St. Louis CardinalsD. Hudson -R | -1½ +145 | -110 | O 7 -120 |
| 982 | Kansas City RoyalsB. Keller -R | +1½ -165 | +100 | U 7 +100 |
| 07:40 PM | ||||
| 959 | Washington NationalsE. Fedde -R | +1½ -140 | +139 | O 10½ -115 |
| 960 | Colorado RockiesG. Marquez -R | -1½ +120 | -150 | U 10½ -105 |
| 09:10 PM | ||||
| 961 | San Francisco GiantsC. Rodon -L | +1½ -170 | +122 | O 6½ -120 |
| 962 | Los Angeles DodgersJ. Urias -L | -1½ +150 | -132 | U 6½ +100 |