Sep 14 Tue 2021
| 2:10 PM | ||||
| 915 | Cleveland Indians - Game #1T. McKenzie -R | +1½ -183 | +110 | O 6½ -125 |
| 916 | Minnesota Twins - Game #1 J. Ryan -R | -1½ +163 | -120 | U 6½ +105 |
| 5:35 PM | ||||
| 901 | Cincinnati RedsW. Miley -L | -1½ +105 | -149 | O 8½ -115 |
| 902 | Pittsburgh PiratesD. Peters -L | +1½ -125 | +138 | U 8½ -105 |
| 5:40 PM | ||||
| 931 | Milwaukee BrewersF. Peralta -R | -1½ -125 | -185 | O 9 -115 |
| 932 | Detroit TigersW. Peralta -R | +1½ +105 | +170 | U 9 -105 |
| 6:05 PM | ||||
| 903 | Chicago CubsA. Sampson -R | +1½ -117 | +175 | O 9 -110 |
| 904 | Philadelphia PhilliesK. Gibson -R | -1½ -103 | -190 | U 9 -110 |
| 6:05 PM | ||||
| 917 | New York YankeesG. Cole -R | -1½ -184 | -300 | O 9 -120 |
| 918 | Baltimore OriolesA. Wells -L | +1½ +164 | +266 | U 9 +100 |
| 6:07 PM | ||||
| 919 | Tampa Bay RaysD. Rasmussen -R | +1½ -160 | +115 | O 9 -115 |
| 920 | Toronto Blue JaysJ. Berrios -R | -1½ +140 | -125 | U 9 -105 |
| 6:10 PM | ||||
| 907 | St. Louis CardinalsJ. Woodford -R | +1½ -150 | +145 | O 8½ +100 |
| 908 | New York MetsM. Stroman -R | -1½ +130 | -157 | U 8½ -120 |
| 6:20 PM | ||||
| 909 | Colorado RockiesJ. Gray -R | +1½ -125 | +165 | O 9 -110 |
| 910 | Atlanta BravesT. Toussaint -R | -1½ +105 | -179 | U 9 -110 |
| 7:05 PM | ||||
| 923 | Houston AstrosZ. Greinke -R | -1½ -135 | -204 | O 9 -115 |
| 924 | Texas RangersJ. Lyles -R | +1½ +115 | +187 | U 9 -105 |
| 7:10 PM | ||||
| 925 | Oakland AthleticsF. Montas -R | -1½ -106 | -155 | O 9 -115 |
| 926 | Kansas City RoyalsJ. Kowar -R | +1½ -114 | +143 | U 9 -105 |
| 8:45 PM | ||||
| 911 | San Diego PadresJ. Arrieta -R | +1½ -146 | +143 | O 8½ -125 |
| 912 | San Francisco GiantsA. Desclafani -R | -1½ +126 | -155 | U 8½ +105 |
| 9:10 PM | ||||
| 913 | Arizona DiamondbacksL. Weaver -R | +1½ +100 | +210 | O 8½ -125 |
| 914 | Los Angeles DodgersT. Gonsolin -R | -1½ -120 | -233 | U 8½ +105 |
| 9:10 PM | ||||
| 929 | Boston Red SoxN. Eovaldi -R | -1½ +110 | -134 | O 8 -115 |
| 930 | Seattle MarinersT. Anderson -L | +1½ -130 | +124 | U 8 -105 |