Jun 29 Tue 2021
| 7:05 PM | ||||
| 901 | Miami MarlinsT. Rogers -L | -116 | O 8 +105 | |
| 902 | Philadelphia PhilliesV. Velasquez -R | +106 | U 8 -125 |
| 7:05 PM | ||||
| 915 | Los Angeles AngelsA. Heaney -L | +142 | O 10 -105 | |
| 916 | New York YankeesJ. Tallion -R | -154 | U 10 -115 |
| 7:05 PM | ||||
| 929 | Tampa Bay RaysR. Hill -L | -114 | O 8½ -115 | |
| 930 | Washington NationalsJ. Ross -R | +104 | U 8½ -105 |
| 7:07 PM | ||||
| 917 | Seattle MarinersC. Flexen -R | +161 | O 10 -105 | |
| 918 | Toronto Blue JaysR. Ray -L | -175 | U 10 -115 |
| 7:10 PM | ||||
| 903 | San Diego PadresB. Snell -L | -151 | O 9½ -105 | |
| 904 | Cincinnati RedsT. Santillan -R | +139 | U 9½ -115 |
| 7:10 PM | ||||
| 919 | Detroit TigersJ. Urena -R | +158 | O 9½ -115 | |
| 920 | Cleveland IndiansJ. Mejia -R | -172 | U 9½ -105 |
| 7:10 PM | ||||
| 921 | Kansas City RoyalsB. Keller -R | +149 | O 10½ -120 | |
| 922 | Boston Red SoxN. Pivetta -R | -162 | U 10½ +100 |
| 7:20 PM | ||||
| 905 | New York MetsT. Megill -R | +143 | O 8½ -120 | |
| 906 | Atlanta BravesC. Morton -R | -155 | U 8½ +100 |
| 8:10 PM | ||||
| 907 | Chicago CubsZ. Davies -R | +176 | O 7 -120 | |
| 908 | Milwaukee BrewersB. Woodruff -R | -192 | U 7 +100 |
| 8:10 PM | ||||
| 923 | Minnesota TwinsB. Ober -R | +126 | O 9 +100 | |
| 924 | Chicago White SoxD. Cease -R | -136 | U 9 -120 |
| 8:15 PM | ||||
| 909 | Arizona DiamondbacksC. Smith -L | +144 | O 8½ -115 | |
| 910 | St. Louis CardinalsC. Martinez -R | -156 | U 8½ -105 |
| 8:40 PM | ||||
| 911 | Pittsburgh PiratesC. De Jong -R | +152 | O 11 +105 | |
| 912 | Colorado RockiesG. Marquez -R | -165 | U 11 -125 |
| 9:40 PM | ||||
| 927 | Texas RangersM. Foltynewicz -R | +157 | O 8½ +100 | |
| 928 | Oakland AthleticsJ. Kaprielian -R | -170 | U 8½ -120 |
| 10:10 PM | ||||
| 913 | San Francisco GiantsK. Gausman -R | +130 | O 7 -120 | |
| 914 | Los Angeles DodgersW. Buehler -R | -140 | U 7 +100 |
