Jun 15 Tue 2021
| 7:05 PM | ||||
| 901 | Pittsburgh PiratesT. Anderson -L | +148 | O 8½ +100 | |
| 902 | Washington NationalsP. Corbin -L+1 Markets | -161 | U 8½ -120 |
| 7:07 PM | ||||
| 915 | New York YankeesJ. Montgomery -L | +108 | O 8½ -125 | |
| 916 | Toronto Blue JaysH. Ryu -L | -118 | U 8½ +105 |
| 7:10 PM | ||||
| 903 | Chicago CubsA. Mills -R | +134 | O 8½ -110 | |
| 904 | New York MetsT. Walker -R+1 Markets | -145 | U 8½ -110 |
| 7:10 PM | ||||
| 917 | Baltimore OriolesM. Harvey -R | +148 | O 9 -120 | |
| 918 | Cleveland IndiansC. Quantrill -R+1 Markets | -161 | U 9 +100 |
| 7:20 PM | ||||
| 929 | Boston Red SoxE. Rodriguez -L | -117 | O 9 -110 | |
| 930 | Atlanta BravesT. Davidson -L | +107 | U 9 -110 |
| 8:10 PM | ||||
| 905 | Cincinnati RedsL. Castillo -R | +100 | O 9 +100 | |
| 906 | Milwaukee BrewersB. Anderson -L+1 Markets | -110 | U 9 -120 |
| 8:10 PM | ||||
| 919 | Detroit TigersC. Mize -R | +134 | O 9 +100 | |
| 920 | Kansas City RoyalsM. Minor -L+1 Markets | -145 | U 9 -120 |
| 8:10 PM | ||||
| 921 | Texas RangersK. Gibson -R | +163 | O 8½ -110 | |
| 922 | Houston AstrosL. McCullers Jr. -R | -177 | U 8½ -110 |
| 8:10 PM | ||||
| 923 | Tampa Bay RaysS. McClanahan -L | +100 | O 8½ -120 | |
| 924 | Chicago White SoxD. Keuchel -L+1 Markets | -110 | U 8½ +100 |
| 8:15 PM | ||||
| 907 | Miami MarlinsT. Rogers -L | +100 | O 7½ -120 | |
| 908 | St. Louis CardinalsK. Kim -L+1 Markets | -110 | U 7½ +100 |
| 8:40 PM | ||||
| 909 | San Diego PadresY. Darvish -R | -210 | O 10½ -117 | |
| 910 | Colorado RockiesC. Gonzalez -R+1 Markets | +192 | U 10½ -103 |
| 9:40 PM | ||||
| 925 | Los Angeles AngelsA. Heaney -L | +115 | O 8½ +110 | |
| 926 | Oakland AthleticsF. Montas -R+1 Markets | -125 | U 8½ -130 |
| 10:10 PM | ||||
| 913 | Philadelphia PhilliesZ. Eflin -R | +161 | O 9 +110 | |
| 914 | Los Angeles DodgersJ. Urias -L+1 Markets | -175 | U 9 -130 |
| 10:10 PM | ||||
| 927 | Minnesota TwinsJ. Happ -L | -110 | O 8½ -105 | |
| 928 | Seattle MarinersC. Flexen -R+1 Markets | +100 | U 8½ -115 |