Jun 1 Tue 2021
| 6:10 PM | ||||
| 911 | Chicago White SoxD. Cease -R | +139 | O 7½ +105 | |
| 912 | Cleveland IndiansS. Bieber -R | -150 | U 7½ -125 |
| 7:05 PM | ||||
| 913 | Minnesota TwinsM. Pineda -R | -160 | O 9 +100 | |
| 914 | Baltimore OriolesB. Zimmermann -L | +148 | U 9 -120 |
| 7:05 PM | ||||
| 915 | Tampa Bay RaysT. Glasnow -R | -125 | O 7½ -115 | |
| 916 | New York YankeesD. German -R | +115 | U 7½ -105 |
| 7:07 PM | ||||
| 921 | Miami MarlinsS. Alcantara -R | +143 | O 8½ -110 | |
| 922 | Toronto Blue JaysR. Ray -L | -155 | U 8½ -110 |
| 7:10 PM | ||||
| 901 | Philadelphia PhilliesA. Nola -R | -107 | O 7½ +105 | |
| 902 | Cincinnati RedsS. Gray -R | -103 | U 7½ -125 |
| 7:20 PM | ||||
| 903 | Washington NationalsS. Strasburg -R | +121 | O 8 -115 | |
| 904 | Atlanta BravesM. Fried -L | -131 | U 8 -105 |
| 7:40 PM | ||||
| 923 | Detroit TigersM. Boyd -L | +139 | O 8 -105 | |
| 924 | Milwaukee BrewersE. Lauer -L | -150 | U 8 -115 |
| 8:10 PM | ||||
| 917 | Boston Red SoxG. Richards -R | +105 | O 9 -120 | |
| 918 | Houston AstrosL. Garcia -R+1 Markets | -115 | U 9 +100 |
| 8:10 PM | ||||
| 925 | Pittsburgh PiratesW. Crowe -R | +164 | O 8½ -105 | |
| 926 | Kansas City RoyalsB. Singer -R | -178 | U 8½ -115 |
| 8:40 PM | ||||
| 927 | Texas RangersD. Dunning -R | +110 | O 10 -105 | |
| 928 | Colorado RockiesG. Marquez -R | -120 | U 10 -115 |
| 9:40 PM | ||||
| 907 | New York MetsD. Peterson -L | -123 | O 9 +105 | |
| 908 | Arizona DiamondbacksC. Smith -L | +113 | U 9 -125 |
| 9:45 PM | ||||
| 929 | Los Angeles AngelsA. Heaney -L | +133 | O 7½ -105 | |
| 930 | San Francisco GiantsA. Wood -L+1 Markets | -144 | U 7½ -115 |
| 10:10 PM | ||||
| 909 | St. Louis CardinalsJ. Gant -R | +154 | O 8 -110 | |
| 910 | Los Angeles DodgersD. Price -L | -167 | U 8 -110 |
| 10:10 PM | ||||
| 919 | Oakland AthleticsC. Bassitt -R | -141 | O 8 +105 | |
| 920 | Seattle MarinersM. Gonzales -L+1 Markets | +130 | U 8 -125 |