May 25 Tue 2021
| 6:40 PM | ||||
| 953 | Philadelphia PhilliesV. Velasquez -R | +118 | O 7 +100 | |
| 954 | Miami MarlinsS. Alcantara -R+1 Markets | -128 | U 7 -120 |
| 7:05 PM | ||||
| 955 | Cincinnati RedsT. Mahle -R | +145 | O 7½ +105 | |
| 956 | Washington NationalsM. Scherzer -R | -157 | U 7½ -125 |
| 7:05 PM | ||||
| 963 | Toronto Blue JaysS. Matz -L | +144 | O 9 -115 | |
| 964 | New York YankeesC. Kluber -R | -156 | U 9 -105 |
| 7:10 PM | ||||
| 957 | Colorado RockiesK. Freeland -L | +216 | O 6½ +105 | |
| 958 | New York MetsJ. Degrom -R+1 Markets | -240 | U 6½ -125 |
| 7:10 PM | ||||
| 965 | Cleveland IndiansA. Civale -R | -135 | O 9 +105 | |
| 966 | Detroit TigersT. Skubal -L+1 Markets | +125 | U 9 -125 |
| 7:10 PM | ||||
| 967 | Kansas City RoyalsB. Keller -R | +151 | O 8½ +100 | |
| 968 | Tampa Bay RaysR. Hill -L | -164 | U 8½ -120 |
| 7:10 PM | ||||
| 975 | Atlanta BravesC. Morton -R | -115 | O 9½ -120 | |
| 976 | Boston Red SoxG. Richards -R | +105 | U 9½ +100 |
| 7:40 PM | ||||
| 959 | San Diego PadresJ. Musgrove -R | +107 | O 7 -110 | |
| 960 | Milwaukee BrewersC. Burnes -R+1 Markets | -117 | U 7 -110 |
| 7:40 PM | ||||
| 969 | Baltimore OriolesD. Kremer -R | +179 | O 9 -115 | |
| 970 | Minnesota TwinsJ. Berrios -R+1 Markets | -195 | U 9 -105 |
| 8:10 PM | ||||
| 977 | Los Angeles DodgersC. Kershaw -L | -122 | O 8 -115 | |
| 978 | Houston AstrosZ. Greinke -R | +112 | U 8 -105 |
| 8:10 PM | ||||
| 979 | St. Louis CardinalsJ. Flaherty -R | +120 | O 8 +100 | |
| 980 | Chicago White SoxL. Giolito -R+1 Markets | -130 | U 8 -120 |
| 9:38 PM | ||||
| 971 | Texas RangersH. Yang -L | +136 | O 8½ -105 | |
| 972 | Los Angeles AngelsA. Heaney -L | -147 | U 8½ -115 |
| 9:40 PM | ||||
| 973 | Seattle MarinersL. Gilbert -R | +152 | O 8 -120 | |
| 974 | Oakland AthleticsC. Irvin -L+1 Markets | -165 | U 8 +100 |