May 4 Tue 2021
| 5:40 PM | ||||
| 929 | Chicago White SoxD. Cease -R | -123 | O 9 -130 | |
| 930 | Cincinnati RedsJ. Hoffman -R | +113 | U 9 +110 |
| 6:05 PM | ||||
| 903 | Atlanta BravesH. Ynoa -R | -135 | O 8½ -124 | |
| 904 | Washington NationalsJ. Ross -R | +125 | U 8½ +104 |
| 6:05 PM | ||||
| 905 | Milwaukee BrewersE. Lauer -L | +172 | O 8 +100 | |
| 906 | Philadelphia PhilliesA. Nola -R+1 Markets | -187 | U 8 -120 |
| 6:05 PM | ||||
| 915 | Houston AstrosZ. Greinke -R | -105 | O 8½ -120 | |
| 916 | New York YankeesD. German -R | -105 | U 8½ +100 |
| 6:40 PM | ||||
| 919 | Texas RangersK. Gibson -R | +130 | O 8½ +100 | |
| 920 | Minnesota TwinsJ. Happ -L+1 Markets | -141 | U 8½ -120 |
| 6:45 PM | ||||
| 909 | New York MetsJ. deGrom -R | -187 | O 6½ -115 | |
| 910 | St. Louis CardinalsK. Kim -L+1 Markets | +172 | U 6½ -105 |
| 7:10 PM | ||||
| 921 | Cleveland IndiansS. Hentges -L | +118 | O 9 -120 | |
| 922 | Kansas City RoyalsM. Minor -L+1 Markets | -128 | U 9 +100 |
| 8:40 PM | ||||
| 925 | Toronto Blue JaysA. Kay -L | -103 | O 9 +100 | |
| 926 | Oakland AthleticsC. Irvin -L+1 Markets | -107 | U 9 -120 |
| 9:10 PM | ||||
| 927 | Baltimore OriolesJ. Lopez -R | +112 | O 8½ -120 | |
| 928 | Seattle MarinersJ. Dunn -R+1 Markets | -122 | U 8½ +100 |