Jul 4 Sun 2021
| 1:05 PM | ||||
| 953 | Milwaukee BrewersF. Peralta -R | -185 | O 8 -115 | |
| 954 | Pittsburgh PiratesT. Anderson -L | +170 | U 8 -105 |
| 1:05 PM | ||||
| 955 | San Diego PadresB. Snell -L | -125 | O 8½ -125 | |
| 956 | Philadelphia PhilliesV. Velasquez -R | +115 | U 8½ +105 |
| 1:10 PM | ||||
| 957 | Chicago CubsK. Hendricks -R | +112 | O 9½ -110 | |
| 958 | Cincinnati RedsW. Miley -L | -122 | U 9½ -110 |
| 1:10 PM | ||||
| 967 | Houston AstrosZ. Greinke -R | -160 | O 9 -120 | |
| 968 | Cleveland IndiansC. Quantrill -R | +148 | U 9 +100 |
| 1:10 PM | ||||
| 969 | Chicago White SoxL. Giolito -R | -170 | O 9 -115 | |
| 970 | Detroit TigersM. Manning -R | +157 | U 9 -105 |
| 1:20 PM | ||||
| 959 | Miami MarlinsZ. Thompson -R | +166 | O 8½ -115 | |
| 960 | Atlanta BravesC. Morton -R | -180 | U 8½ -105 |
| 2:05 PM | ||||
| 981 | New York Mets - Game #1M. Stroman -R | +163 | O 6 -120 | |
| 982 | New York Yankees - Game #1G. Cole -R | -177 | U 6 +100 |
| 2:10 PM | ||||
| 971 | Minnesota TwinsK. Maeda -R | -130 | O 10 -120 | |
| 972 | Kansas City RoyalsB. Keller -R | +120 | U 10 +100 |
| 3:10 PM | ||||
| 961 | St. Louis CardinalsC. Martinez -R | +130 | O 11½ +105 | |
| 962 | Colorado RockiesG. Marquez -R | -140 | U 11½ -125 |
| 4:07 PM | ||||
| 973 | Boston Red SoxN. Pivetta -R | -102 | O 9 -105 | |
| 974 | Oakland AthleticsJ. Kaprielian -R | -108 | U 9 -115 |
| 4:07 PM | ||||
| 975 | Baltimore OriolesT. Eshelman -R | +184 | O 10 -105 | |
| 976 | Los Angeles AngelsP. Sandoval -L | -201 | U 10 -115 |
| 4:10 PM | ||||
| 977 | Texas RangersM. Foltynewicz -R | +130 | O 8½ -125 | |
| 978 | Seattle MarinersC. Flexen -R | -140 | U 8½ +105 |
| 9:10 PM | ||||
| 963 | San Francisco GiantsA. Desclafani -R | -150 | O 9 +100 | |
| 964 | Arizona DiamondbacksC. Smith -L | +139 | U 9 -120 |
