Sep 6 Mon 2021
| 12:05 PM | ||||
| 901 | New York MetsT. Williams -R | -1½ +130 | -118 | O 9 -110 |
| 902 | Washington NationalsP. Corbin -L | +1½ -150 | +108 | U 9 -110 |
| 12:05 PM | ||||
| 913 | Toronto Blue JaysH. Ryu -L | +1½ -160 | +116 | O 9½ -110 |
| 914 | New York YankeesJ. Taillon -R | -1½ +140 | -126 | U 9½ -110 |
| 12:35 PM | ||||
| 923 | Detroit TigersT. Skubal -L | -1½ +125 | -124 | O 8½ -110 |
| 924 | Pittsburgh PiratesB. Wilson -R | +1½ -145 | +114 | U 8½ -110 |
| 1:10 PM | ||||
| 903 | Philadelphia PhilliesZ. Wheeler -R | +1½ -165 | +129 | O 7½ -120 |
| 904 | Milwaukee BrewersB. Woodruff -R | -1½ +145 | -139 | U 7½ +100 |
| 3:10 PM | ||||
| 907 | San Francisco GiantsK. Gausman -R | -1½ -115 | -170 | O 11 -110 |
| 908 | Colorado RockiesK. Freeland -L | +1½ -105 | +157 | U 11 -110 |
| 3:15 PM | ||||
| 909 | Los Angeles DodgersM. Scherzer -R | -1½ -125 | -210 | O 8 +100 |
| 910 | St. Louis CardinalsM. Mikolas -R | +1½ +105 | +192 | U 8 -120 |
| 5:10 PM | ||||
| 917 | Minnesota TwinsB. Ober -R | -1½ +135 | -113 | O 9 -125 |
| 918 | Cleveland IndiansL. Allen -L | +1½ -155 | +103 | U 9 +105 |
| 6:10 PM | ||||
| 919 | Seattle MarinersY. Kikuchi -L | +1½ -110 | +188 | O 8½ -105 |
| 920 | Houston AstrosL. McCullers Jr. -R | -1½ -110 | -205 | U 8½ -115 |
| 8:07 PM | ||||
| 921 | Texas RangersA. Alexy -R | +1½ -140 | +136 | O 9 -115 |
| 922 | Los Angeles AngelsJ. Barria -R | -1½ +120 | -147 | U 9 -105 |
