Jun 28 Mon 2021
| 5:10 PM | ||||
| 951 | Pittsburgh PiratesT. Anderson -L | +113 | O 11 +100 | |
| 952 | Colorado RockiesK. Freeland -L | -123 | U 11 -120 |
| 6:40 PM | ||||
| 953 | Philadelphia PhilliesS. Howard -R | +134 | O 9½ -120 | |
| 954 | Cincinnati RedsW. Miley -L | -145 | U 9½ +100 |
| 7:05 PM | ||||
| 963 | Los Angeles AngelsD. Bundy -R | +130 | O 9½ -115 | |
| 964 | New York YankeesM. King -R | -141 | U 9½ -105 |
| 7:10 PM | ||||
| 965 | Detroit TigersM. Manning -R | +128 | O 9½ -105 | |
| 966 | Cleveland IndiansE. Morgan -R | -138 | U 9½ -115 |
| 7:10 PM | ||||
| 967 | Kansas City RoyalsD. Duffy -L | +136 | O 10 -110 | |
| 968 | Boston Red SoxG. Richards -R | -147 | U 10 -110 |
| 8:10 PM | ||||
| 957 | Chicago CubsK. Hendricks -R | +128 | O 7½ +105 | |
| 958 | Milwaukee BrewersF. Peralta -R | -138 | U 7½ -125 |
| 8:10 PM | ||||
| 969 | Minnesota TwinsK. Maeda -R | +130 | O 8 -120 | |
| 970 | Chicago White SoxL. Giolito -R | -141 | U 8 +100 |
| 8:10 PM | ||||
| 971 | Baltimore OriolesT. Eshelman -R | +266 | O 9½ +100 | |
| 972 | Houston AstrosZ. Greinke -R | -300 | U 9½ -120 |
| 8:15 PM | ||||
| 959 | Arizona DiamondbacksJ. Faria -R | +141 | O 9½ +100 | |
| 960 | St. Louis CardinalsW. Leblanc -L | -153 | U 9½ -120 |
| 10:10 PM | ||||
| 961 | San Francisco GiantsA. Desclafani -R | +172 | O 7½ -110 | |
| 962 | Los Angeles DodgersT. Bauer -R | -187 | U 7½ -110 |
