Apr 5 Mon 2021
| 12:10 PM | ||||
| 963 | Minnesota TwinsM. Shoemaker -R | -1½ +110 | -143 | O 8½ -125 |
| 964 | Detroit Tigers J. Urena -R | +1½ -130 | +132 | U 8½ +105 |
| 3:05 PM | ||||
| 951 | Atlanta BravesD. Smyly -L | +1½ -150 | +129 | O 8 -115 |
| 952 | Washington Nationals M. Scherzer -R | -1½ +130 | -139 | U 8 -105 |
| 3:05 PM | ||||
| 965 | Toronto Blue JaysS. Matz -L | -1½ -110 | -152 | O 9½ -105 |
| 966 | Texas Rangers M. Foltynewicz -R | +1½ -110 | +140 | U 9½ -115 |
| 3:10 PM | ||||
| 967 | Kansas City RoyalsD. Duffy -L | -1½ +140 | -105 | O 8½ -120 |
| 968 | Cleveland Indians L. Allen -L | +1½ -160 | -105 | U 8½ +100 |
| 5:35 PM | ||||
| 969 | Baltimore OriolesJ. Lopez -R | +1½ -105 | +204 | O 9½ -125 |
| 970 | New York Yankees J. Montgomery -L | -1½ -115 | -225 | U 9½ +105 |
| 5:40 PM | ||||
| 953 | St. Louis CardinalsD. Ponce De Leon -R | +1½ -210 | -101 | O 8½ -110 |
| 954 | Miami Marlins T. Rogers -L | -1½ +180 | -109 | U 8½ -110 |
| 5:40 PM | ||||
| 955 | Pittsburgh PiratesJ. Brubaker -R | +1½ -155 | +127 | O 9½ +100 |
| 956 | Cincinnati Reds J. De Leon -R | -1½ +135 | -137 | U 9½ -120 |
| 6:05 PM | ||||
| 957 | New York MetsJ. Degrom -R | -1½ -125 | -200 | O 7½ -110 |
| 958 | Philadelphia Phillies M. Moore -L | +1½ +105 | +184 | U 7½ -110 |
| 6:10 PM | ||||
| 971 | Tampa Bay RaysM. Wacha -R | -1½ +130 | -117 | O 9½ -110 |
| 972 | Boston Red Sox N. Pivetta -R | +1½ -150 | +107 | U 9½ -110 |
| 8:38 PM | ||||
| 973 | Houston AstrosL. Garcia -R | +1½ -180 | +105 | O 9 -115 |
| 974 | Los Angeles Angels J. Quintana -L | -1½ +160 | -115 | U 9 -105 |
| 8:40 PM | ||||
| 977 | Los Angeles DodgersD. May -R | -1½ +100 | -145 | O 8½ -120 |
| 978 | Oakland Athletics F. Montas -R | +1½ -120 | +134 | U 8½ +100 |
| 9:10 PM | ||||
| 961 | San Francisco GiantsA. Desclafani -R | +1½ -130 | +157 | O 8½ -110 |
| 962 | San Diego Padres A. Morejon -L | -1½ +110 | -170 | U 8½ -110 |
| 9:10 PM | ||||
| 975 | Chicago White SoxC. Rodon -L | -1½ +130 | -124 | O 8½ -110 |
| 976 | Seattle Mariners J. Sheffield -L | +1½ -150 | +114 | U 8½ -110 |