In his two home starts at Chase Field Nuno went 11.2 IP and allowed 3 R on 10 H with 2 BB and 5 K. He started a game versus the Bucs back on May 18, so he has some history with these batters - they've at least seen him once.
Volquez did pretty well on Sep 10 last season at 'Zona after making his previous start at Coors Field. That's what sticks out is that in his last outing he only lasted 4.1 innings at Coors.