Apr 29 Fri 2022
| 05:35 PM | ||||
| 951 | San Diego PadresY. Darvish -R | -1½ -105 | -182 | O 7½ +105 |
| 952 | Pittsburgh PiratesZ. Thompson -R | +1½ -115 | +167 | U 7½ -125 |
| 05:40 PM | ||||
| 975 | Seattle MarinersM. Brash -R | -1½ +145 | -113 | O 7½ -105 |
| 976 | Miami MarlinsE. Hernandez -R | +1½ -165 | +103 | U 7½ -115 |
| 06:05 PM | ||||
| 963 | Boston Red SoxR. Hill -L | -130 | O 9 +100 | |
| 964 | Baltimore OriolesK. Bradish -R | +120 | U 9 -120 |
| 06:07 PM | ||||
| 965 | Houston AstrosJ. Urquidy -R | +1½ -195 | +105 | O 8½ -105 |
| 966 | Toronto Blue JaysY. Kikuchi -L | -1½ +170 | -115 | U 8½ -115 |
| 06:10 PM | ||||
| 953 | Philadelphia PhilliesA. Nola -R | +1½ -210 | +105 | O 7 -110 |
| 954 | New York MetsT. Megill -R | -1½ +180 | -115 | U 7 -110 |
| 06:10 PM | ||||
| 967 | Minnesota TwinsD. Bundy -R | +1½ -180 | +120 | O 8 +105 |
| 968 | Tampa Bay RaysC. Kluber -R | -1½ +160 | -130 | U 8 -125 |
| 06:10 PM | ||||
| 969 | Los Angeles AngelsN. Syndergaard -R | +1½ -195 | +111 | O 7 +100 |
| 970 | Chicago White SoxL. Giolito -R | -1½ +170 | -121 | U 7 -120 |
| 07:10 PM | ||||
| 955 | Chicago CubsK. Hendricks -R | +130 | O 8 +100 | |
| 956 | Milwaukee BrewersA. Houser -R | -140 | U 8 -120 |
| 07:10 PM | ||||
| 971 | New York YankeesN. Cortes -L | -1½ -130 | -200 | O 8 -115 |
| 972 | Kansas City RoyalsK. Bubic -L | +1½ +110 | +184 | U 8 -105 |
| 07:15 PM | ||||
| 957 | Arizona DiamondbacksM. Bumgarner -L | +1½ -140 | +170 | O 7 -120 |
| 958 | St. Louis CardinalsA. Wainwright -R | -1½ +120 | -185 | U 7 +100 |
| 07:40 PM | ||||
| 959 | Cincinnati RedsH. Greene -R | +1½ -180 | +110 | O 10½ -110 |
| 960 | Colorado RockiesA. Senzatela -R | -1½ +160 | -120 | U 10½ -110 |
| 08:40 PM | ||||
| 973 | Cleveland GuardiansA. Civale -R | +1½ -183 | +125 | O 7 +110 |
| 974 | Oakland AthleticsF. Montas -R+1 Markets | -1½ +163 | -135 | U 7 -130 |
| 09:10 PM | ||||
| 979 | Detroit TigersT. Alexander -L | +1½ +105 | +216 | O 8½ +100 |
| 980 | Los Angeles DodgersT. Anderson -L | -1½ -125 | -240 | U 8½ -120 |
| 09:15 PM | ||||
| 961 | Washington NationalsA. Sanchez -R | +1½ -110 | +196 | O 7½ -105 |
| 962 | San Francisco GiantsA. Wood -L | -1½ -110 | -215 | U 7½ -115 |