Apr 22 Fri 2022
| 05:40 PM | ||||
| 903 | St. Louis CardinalsS. Matz -L | -1½ +125 | -127 | O 8½ -110 |
| 904 | Cincinnati RedsH. Greene -R | +1½ -145 | +117 | U 8½ -110 |
| 06:05 PM | ||||
| 907 | Milwaukee BrewersF. Peralta -R | +1½ -180 | +111 | O 8 -105 |
| 908 | Philadelphia PhilliesR. Suarez -L | -1½ +160 | -121 | U 8 -115 |
| 06:10 PM | ||||
| 917 | Boston Red SoxM. Wacha -R | +1½ -165 | +123 | O 8½ +105 |
| 918 | Tampa Bay RaysC. Kluber -R | -1½ +145 | -133 | U 8½ -125 |
| 06:10 PM | ||||
| 929 | Colorado RockiesA. Senzatela -R | +1½ -170 | +120 | O 8 -105 |
| 930 | Detroit TigersT. Skubal -L | -1½ +150 | -130 | U 8 -115 |
| 06:20 PM | ||||
| 909 | Miami MarlinsT. Rogers -L | +1½ -150 | +130 | O 8 -115 |
| 910 | Atlanta BravesK. Wright -R | -1½ +130 | -140 | U 8 -105 |
| 07:10 PM | ||||
| 919 | Toronto Blue JaysR. Stripling -R | +1½ -140 | +150 | O 8½ -105 |
| 920 | Houston AstrosJ. Verlander -R | -1½ +120 | -163 | U 8½ -115 |
| 07:10 PM | ||||
| 921 | Chicago White SoxM. Kopech -R | +1½ -195 | -103 | O 8 +103 |
| 922 | Minnesota TwinsB. Ober -R | -1½ +170 | -107 | U 8 -123 |
| 08:38 PM | ||||
| 923 | Baltimore OriolesB. Zimmermann -L | +1½ -125 | +161 | O 8½ -115 |
| 924 | Los Angeles AngelsR. Detmers -L | -1½ +105 | -175 | U 8½ -105 |
| 08:40 PM | ||||
| 911 | New York MetsD. Peterson -L | -1½ +125 | -125 | O 8½ +105 |
| 912 | Arizona DiamondbacksZ. Gallen -R | +1½ -145 | +115 | U 8½ -125 |
| 08:40 PM | ||||
| 913 | Los Angeles DodgersJ. Urias -L | -1½ -110 | -168 | O 8 -115 |
| 914 | San Diego PadresN. Martinez -R | +1½ -110 | +155 | U 8 -105 |
| 08:40 PM | ||||
| 925 | Kansas City RoyalsB. Keller -R | +1½ -170 | +122 | O 8 +107 |
| 926 | Seattle MarinersC. Flexen -R | -1½ +150 | -132 | U 8 -127 |