Sep 10 Fri 2021
| 6:10 PM | ||||
| 915 | Tampa Bay RaysM. Wacha -R | -1½ -110 | -160 | O 9½ +103 |
| 916 | Detroit TigersM. Boyd -L | +1½ -110 | +148 | U 9½ -123 |
| 6:10 PM | ||||
| 925 | Milwaukee BrewersA. Houser -R | -1½ -105 | -155 | O 9½ -110 |
| 926 | Cleveland IndiansE. Morgan -R | +1½ -115 | +143 | U 9½ -110 |
| 7:10 PM | ||||
| 919 | Los Angeles AngelsS. Ohtani -R | +1½ -125 | +166 | O 8 -115 |
| 920 | Houston AstrosF. Valdez -L | -1½ +105 | -181 | U 8 -105 |
| 7:15 PM | ||||
| 909 | Cincinnati RedsT. Mahle -R | -1½ +110 | -132 | O 8½ -120 |
| 910 | St. Louis CardinalsJ. Lester -L | +1½ -130 | +122 | U 8½ +100 |
| 8:40 PM | ||||
| 923 | Texas RangersG. Otto -R | +1½ -125 | +161 | O 8½ -110 |
| 924 | Oakland AthleticsP. Blackburn -R | -1½ +105 | -175 | U 8½ -110 |
| 9:10 PM | ||||
| 911 | San Diego PadresJ. Musgrove -R | +1½ -145 | +143 | O 8 -115 |
| 912 | Los Angeles DodgersJ. Urias -L | -1½ +125 | -155 | U 8 -105 |