Jun 4 Fri 2021
| 7:05 PM | ||||
| 951 | Washington NationalsM. Scherzer -R | -105 | O 7 +110 | |
| 952 | Philadelphia PhilliesZ. Wheeler -R | -105 | U 7 -130 |
| 7:05 PM | ||||
| 953 | Miami MarlinsC. Poteet -R | -114 | O 7½ -110 | |
| 954 | Pittsburgh PiratesM. Keller -R+1 Markets | +104 | U 7½ -110 |
| 7:05 PM | ||||
| 967 | Cleveland IndiansJ. Mejia -R | -110 | O 9 -115 | |
| 968 | Baltimore OriolesK. Akin -L | +100 | U 9 -105 |
| 7:07 PM | ||||
| 969 | Houston AstrosZ. Greinke -R | +110 | O 8½ -105 | |
| 970 | Toronto Blue JaysH. Ryu -L | -120 | U 8½ -115 |
| 7:20 PM | ||||
| 955 | Los Angeles DodgersJ. Urias -L | -118 | O 9 +105 | |
| 956 | Atlanta BravesI. Anderson -R | +108 | U 9 -125 |
| 8:10 PM | ||||
| 975 | Detroit TigersS. Turnbull -R | +152 | O 8½ -105 | |
| 976 | Chicago White SoxD. Keuchel -L+1 Markets | -165 | U 8½ -115 |
| 8:15 PM | ||||
| 959 | Cincinnati RedsL. Castillo -R | +115 | O 8 -120 | |
| 960 | St. Louis CardinalsK. Kim -L+1 Markets | -125 | U 8 +100 |
| 8:40 PM | ||||
| 979 | Oakland AthleticsF. Montas -R | -130 | O 10½ -105 | |
| 980 | Colorado RockiesJ. Gray -R | +120 | U 10½ -115 |
