May 21 Fri 2021
| 7:05 PM | ||||
| 963 | Chicago White SoxC. Rodon -L | -105 | O 8½ -115 | |
| 964 | New York YankeesJ. Montgomery -L | -105 | U 8½ -105 |
| 7:05 PM | ||||
| 975 | Baltimore OriolesJ. Lopez -R | +179 | O 8½ -105 | |
| 976 | Washington NationalsS. Strasburg -R | -195 | U 8½ -115 |
| 7:05 PM | ||||
| 977 | Boston Red SoxM. Perez -L | +150 | O 8 -115 | |
| 978 | Philadelphia PhilliesA. Nola -R | -163 | U 8 -105 |
| 7:10 PM | ||||
| 951 | New York MetsM. Stroman -R | +139 | O 7 -110 | |
| 952 | Miami MarlinsP. Lopez -R | -150 | U 7 -110 |
| 7:10 PM | ||||
| 953 | Milwaukee BrewersA. Houser -R | -112 | O 9 -115 | |
| 954 | Cincinnati RedsJ. Hoffman -R | +102 | U 9 -105 |
| 7:10 PM | ||||
| 965 | Minnesota TwinsK. Maeda -R | +100 | O 8½ -115 | |
| 966 | Cleveland IndiansT. McKenzie -R | -110 | U 8½ -105 |
| 7:20 PM | ||||
| 955 | Pittsburgh PiratesT. Anderson -L | +170 | O 8 -120 | |
| 956 | Atlanta BravesI. Anderson -R+1 Markets | -185 | U 8 +100 |
| 7:37 PM | ||||
| 967 | Tampa Bay RaysT. Glasnow -R | -140 | O 9 +100 | |
| 968 | Toronto Blue JaysA. Kay -L | +130 | U 9 -120 |
| 8:05 PM | ||||
| 969 | Houston AstrosT. Ivey -R | -120 | O 8½ -120 | |
| 970 | Texas RangersK. Gibson -R | +110 | U 8½ +100 |
| 8:10 PM | ||||
| 971 | Detroit TigersJ. Urena -R | +139 | O 9 +100 | |
| 972 | Kansas City RoyalsM. Minor -L | -151 | U 9 -120 |
| 8:15 PM | ||||
| 957 | Chicago CubsK. Hendricks -R | -112 | O 7½ -125 | |
| 958 | St. Louis CardinalsC. Martinez -R | +102 | U 7½ +105 |
| 9:38 PM | ||||
| 973 | Oakland AthleticsJ. Kaprielian -R | -121 | O 9 -115 | |
| 974 | Los Angeles AngelsJ. Quintana -L | +111 | U 9 -105 |
| 9:45 PM | ||||
| 961 | Los Angeles DodgersT. Bauer -R | -155 | O 6½ -115 | |
| 962 | San Francisco GiantsA. Wood -L | +143 | U 6½ -105 |
| 10:10 PM | ||||
| 979 | Seattle MarinersC. Flexen -R | +179 | O 7½ -120 | |
| 980 | San Diego PadresC. Paddack -R | -195 | U 7½ +100 |