| 12:00 PM | Michigan State @ 24 Miami | ABC | Joe Tessitore, Greg McElroy |
| 12:00 PM | Nebraska @ 3 Oklahoma | FOX | Gus Johnson, Joel Klatt |
| 12:00 PM | 8 Cincinnati @ Indiana | ESPN | Dave Pasch, Dusty Dvoracek, Tom Luginbill |
| 12:00 PM | 16 Coastal Carolina @ Buffalo | ESPN2 | John Schriffen, Rene Ingoglia |
| 12:00 PM | 15 Virginia Tech @ West Virginia | FS1 | Cory Provus, Devin Gardner |
| 12:00 PM | Boston College @ Temple | ESPNU | Brian Custer, Kelly Stouffer |
| 12:00 PM | New Mexico @ 7 Texas A&M | SECN | Taylor Zarzour, Matt Stinchcomb |
| 12:00 PM | Northern Illinois @ 25 Michigan | BTN | Brandon Gaudin, James Laurinaitis |
| 12:00 PM | Albany @ Syracuse | ACCN | Chris Cotter, Mark Herzlich |
| 12:00 PM | Connecticut @ Army | CBSSN | Jason Horowitz, Ross Tucker |
| 12:00 PM | Western Michigan @ Pittsburgh | ACC RSNs | Tom Werme, James Bates |
| 12:00 PM | Chattanooga @ Kentucky | ESPN+ | Mike Morgan, Ben Hartsock |
| 12:00 PM | Southeast Missouri State @ Missouri | ESPN+ | Roy Philpott, Dave Steckel |
| 12:00 PM | Tennessee Tech @ Tennessee | ESPN+ | Kevin Brown, Hutson Mason |
| 1:00 PM | Minnesota @ Colorado | P12N | Roxy Bernstein, Lincoln Kennedy |
| 2:00 PM | Nevada @ Kansas State | ESPN+ | Shawn Kenney, Barrett Brooks |
| 2:30 PM | Purdue @ 12 Notre Dame | NBC | Mike Tirico, Drew Brees |
| 3:30 PM | Georgia Tech @ 6 Clemson | ABC | Bob Wischusen, Dan Orlovsky |
| 3:30 PM | 1 Alabama @ 11 Florida | CBS | Brad Nessler, Gary Danielson |
| 3:30 PM | USC @ Washington State | FOX | Joe Davis, Brock Huard |
| 3:30 PM | Wake Forest @ Florida State | ESPN | Asshole Mark Jones, Robert Griffin III, Quint Kessenich |
| 3:30 PM | Tulsa @ 9 Ohio State | FS1 | Tim Brando, Spencer Tillman |
| 3:30 PM | Delaware @ Rutgers | BTN | Lisa Byington, Matt Millen |
| 3:30 PM | Kent State @ 5 Iowa | BTN | Mark Followill, Anthony Herron |
| 3:30 PM | Idaho @ Oregon State | P12N (OR) | Rich Burk, Nigel Burton |
| 3:30 PM | Southern Methodist @ Louisiana Tech | CBSSN | Chick Hernandez, Ben Leber |
| 3:30 PM | Eastern Michigan @ Massachusetts | NESN+, FloSports | |
| 3:30 PM | Baylor @ Kansas | ESPN+ | Courtney Lyle, Ryan Leaf |
| 3:30 PM | Elon @ Appalachian State | ESPN+ | |
| 3:30 PM | Long Island @ Miami (OH) | ESPN+ | |
| 3:30 PM | Bryant @ Akron | ESPN3 | |
| 4:00 PM | Mississippi State @ Memphis | ESPN2 | Beth Mowins, Kirk Morrison |
| 4:00 PM | Colorado State @ Toledo | ESPNU | Mike Couzens, Dustin Fox |
| 4:00 PM | Georgia Southern @ 20 Arkansas | SECN | Dave Neal, Deuce McAllister |
| 4:00 PM | Sacramento State @ California | P12N (BA) | Jim Kozimor, Bob Davie |
| 4:00 PM | Northwestern @ Duke | ACCN | Wes Durham, Roddy Jones |
| 4:00 PM | Ball State @ Wyoming | Stadium | |
| 4:15 PM | Arkansas State @ Washington | P12N | JB Long, Max Browne |
| 5:00 PM | Murray State @ Bowling Green | ESPN3 | |
| 6:00 PM | East Carolina @ Marshall | CBS Sports Facebook | Michael Grady, Corey Chavous |
| 6:00 PM | Middle Tennessee @ UTSA | ESPN+ | |
| 6:00 PM | Fordham @ Florida Atlantic | ESPN3 | |
| 6:00 PM | Old Dominion @ Liberty | ESPN3 | |
| 7:00 PM | South Carolina @ 2 Georgia | ESPN | Sean McDonough, Todd Blackledge |
| 7:00 PM | Utah @ San Diego State
(in Carson) | CBSSN | Dave Ryan, Aaron Murray |
| 7:00 PM | Charlotte @ Georgia State | ESPN+ | |
| 7:00 PM | Florida A&M @ South Florida | ESPN+ | |
| 7:00 PM | Florida International @ Texas Tech | ESPN+ | Mark Neely, Brandon Jacobs |
| 7:00 PM | Grambling State @ Houston | ESPN+ | |
| 7:00 PM | Troy @ Southern Mississippi | ESPN+ | |
| 7:00 PM | Incarnate Word @ Texas State | ESPN3 | |
| 7:30 PM | 22 Auburn @ 10 Penn State | ABC | Chris Fowler, Kirk Herbstreit |
| 7:30 PM | Utah State @ Air Force | FS2 | Cory Provus, Devin Gardner |
| 7:30 PM | Central Michigan @ LSU | SECN | Tom Hart, Jordan Rodgers, Cole Cubelic |
| 7:30 PM | Stony Brook @ 4 Oregon | P12N | Guy Haberman, Shane Vereen |
| 7:30 PM | Virginia @ 21 North Carolina | ACCN | Dave O'Brien, Tim Hasselbeck |
| 7:30 PM | Furman @ N.C. State | ACC RSNs | Evan Lepler, Charles Arbuckle |
| 7:30 PM | UAB @ North Texas | Stadium | |
| 8:00 PM | Tulane @ 17 Ole Miss | ESPN2 | Anish Shroff, Mike Golic Jr. |
| 8:00 PM | Stanford @ Vanderbilt | ESPNU | Clay Matvick, Rocky Boiman |
| 8:00 PM | Rice @ Texas | Longhorn Network | Lowell Galindo, Sam Acho |
| 8:00 PM | South Carolina State @ New Mexico State | CW El Paso, FloSports | |
| 8:00 PM | Alcorn State @ South Alabama | ESPN3 | |
| 8:00 PM | Jackson State @ ULM | ESPN3 | |
| 9:00 PM | Oklahoma State @ Boise State | FS1 | Aaron Goldsmith, Mark Helfrich |
| 10:00 PM | Northern Arizona @ Arizona | P12N (AZ) | Chris Fisher, Lance Briggs |
| 10:15 PM | 19 Arizona State @ 23 BYU | ESPN | Dave Flemming, Rod Gilmore |
| 10:30 PM | Iowa State @ UNLV | CBSSN | Rich Waltz, Aaron Taylor |
| 10:45 PM | Fresno State @ 13 UCLA | P12N | Ted Robinson, Yogi Roth |
| 12:30 AM | San Jose State @ Hawaii | FS1 | Alex Faust, Petros Papadakis |
