Apr 27 Wed 2022
| 12:15 PM | ||||
| 951 | New York MetsC. Carrasco -R | -1½ +150 | -118 | O 7 -115 |
| 952 | St. Louis CardinalsS. Matz -L | +1½ -170 | +108 | U 7 -105 |
| 01:10 PM | ||||
| 971 | Kansas City RoyalsZ. Greinke -R | +1½ -140 | +166 | O 7 -110 |
| 972 | Chicago White SoxD. Cease -R | -1½ +120 | -181 | U 7 -110 |
| 02:40 PM | ||||
| 953 | Los Angeles DodgersJ. Urias -L | -1½ -119 | -180 | O 8 -105 |
| 954 | Arizona DiamondbacksZ. Gallen -R | +1½ -101 | +166 | U 8 -115 |
| 05:35 PM | ||||
| 955 | Milwaukee BrewersA. Ashby -L | -1½ -104 | -171 | O 7½ -113 |
| 956 | Pittsburgh PiratesB. Wilson -R | +1½ -116 | +157 | U 7½ -107 |
| 05:40 PM | ||||
| 957 | San Diego PadresM. Gore -L | -1½ -103 | -173 | O 8½ -112 |
| 958 | Cincinnati RedsV. Gutierrez -R | +1½ -117 | +159 | U 8½ -108 |
| 05:45 PM | ||||
| 959 | Colorado RockiesR. Feltner -R | +1½ -111 | +196 | O 8½ -102 |
| 960 | Philadelphia PhilliesR. Suarez -L | -1½ -109 | -215 | U 8½ -118 |
| 06:05 PM | ||||
| 961 | Miami MarlinsP. Lopez -R | -1½ +120 | -146 | O 7½ +100 |
| 962 | Washington NationalsE. Fedde -R | +1½ -140 | +135 | U 7½ -120 |
| 06:05 PM | ||||
| 967 | Baltimore OriolesT. Wells -R | +1½ +103 | +224 | O 8 -112 |
| 968 | New York YankeesJ. Montgomery -L | -1½ -123 | -250 | U 8 -108 |
| 06:07 PM | ||||
| 969 | Boston Red SoxM. Wacha -R | +1½ -160 | +130 | O 9 +105 |
| 970 | Toronto Blue JaysR. Stripling -R | -1½ +140 | -141 | U 9 -125 |
| 06:20 PM | ||||
| 963 | Chicago CubsM. Leiter -R | +1½ -113 | +179 | O 8½ +100 |
| 964 | Atlanta BravesC. Morton -R | -1½ -107 | -195 | U 8½ -120 |
| 06:40 PM | ||||
| 973 | Detroit TigersM. Pineda -R | +1½ -135 | +165 | O 7 -115 |
| 974 | Minnesota TwinsJ. Ryan -R | -1½ +115 | -179 | U 7 -105 |
| 07:05 PM | ||||
| 975 | Houston AstrosC. Javier -R | -1½ +137 | -123 | O 8½ -105 |
| 976 | Texas RangersG. Otto -R | +1½ -157 | +113 | U 8½ -115 |
| 08:38 PM | ||||
| 977 | Cleveland GuardiansZ. Plesac -R | +1½ -125 | +179 | O 7½ -110 |
| 978 | Los Angeles AngelsS. Ohtani -R | -1½ +105 | -195 | U 7½ -110 |