Apr 20 Wed 2022
| 12:40 PM | ||||
| 901 | Pittsburgh PiratesM. Keller -R | +1½ +105 | +211 | O 8 -102 |
| 902 | Milwaukee BrewersB. Woodruff -R+1 Markets | -1½ -125 | -234 | U 8 -118 |
| 02:10 PM | ||||
| 903 | Philadelphia PhilliesZ. Eflin -R | -1½ +125 | -115 | O 11 -102 |
| 904 | Colorado RockiesG. Marquez -R+1 Markets | +1½ -145 | +105 | U 11 -118 |
| 02:10 PM | ||||
| 905 | Atlanta BravesC. Morton -R | +1½ -165 | +122 | O 8½ -115 |
| 906 | Los Angeles DodgersT. Gonsolin -R+1 Markets | -1½ +145 | -132 | U 8½ -105 |
| 03:10 PM | ||||
| 907 | Cincinnati RedsV. Gutierrez -R | +1½ -125 | +167 | O 8½ -105 |
| 908 | San Diego PadresM. Gore -L+1 Markets | -1½ +105 | -182 | U 8½ -115 |
| 05:07 PM | ||||
| 927 | Baltimore OriolesJ. Lyles -R | +1½ -175 | +120 | O 8 -110 |
| 928 | Oakland AthleticsD. Jefferies -R+1 Markets | -1½ +155 | -130 | U 8 -110 |
| 05:40 PM | ||||
| 917 | New York YankeesL. Severino -R | -1½ -105 | -155 | O 7½ -107 |
| 918 | Detroit TigersE. Rodriguez -L+1 Markets | +1½ -115 | +143 | U 7½ -113 |
| 06:05 PM | ||||
| 911 | Arizona DiamondbacksM. Kelly -R | +1½ -180 | +111 | O 8½ -105 |
| 912 | Washington NationalsE. Fedde -R+1 Markets | -1½ +160 | -121 | U 8½ -115 |
| 06:10 PM | ||||
| 913 | San Francisco GiantsC. Rodon -L | -1½ +155 | -108 | O 7 +113 |
| 914 | New York MetsC. Bassitt -R+1 Markets | +1½ -175 | -102 | U 7 -133 |
| 06:10 PM | ||||
| 921 | Toronto Blue JaysJ. Berrios -R | -1½ +120 | -125 | O 9½ +108 |
| 922 | Boston Red SoxN. Pivetta -R+1 Markets | +1½ -140 | +115 | U 9½ -128 |
| 07:10 PM | ||||
| 923 | Minnesota TwinsC. Paddack -R | -1½ +120 | -122 | O 9 -105 |
| 924 | Kansas City RoyalsD. Lynch -L+1 Markets | +1½ -140 | +112 | U 9 -115 |
| 08:40 PM | ||||
| 925 | Texas RangersD. Dunning -R | +1½ -160 | +130 | O 8 -107 |
| 926 | Seattle MarinersL. Gilbert -R+1 Markets | -1½ +140 | -140 | U 8 -113 |