Jul 21 Wed 2021
| 12:35 PM | ||||
| 953 | New York MetsM. Stroman -R | -1½ +115 | -130 | O 10½ -125 |
| 954 | Cincinnati RedsJ. Hoffman -R | +1½ -135 | +120 | U 10½ +105 |
| 2:10 PM | ||||
| 973 | Kansas City RoyalsB. Keller -R | +1½ -135 | +149 | O 9½ +100 |
| 974 | Milwaukee BrewersE. Lauer -L | -1½ +115 | -162 | U 9½ -120 |
| 7:07 PM | ||||
| 965 | Boston Red SoxT. Houck -R | +1½ -120 | +152 | O 11 +115 |
| 966 | Toronto Blue JaysR. Ray -L | -1½ +100 | -165 | U 11 -135 |
| 8:10 PM | ||||
| 969 | Cleveland IndiansE. Morgan -R | +1½ +110 | +224 | O 9 -120 |
| 970 | Houston AstrosL. McCullers Jr. -R | -1½ -130 | -250 | U 9 +100 |
| 8:10 PM | ||||
| 971 | Minnesota TwinsM. Pineda -R | +1½ -155 | +129 | O 9 -120 |
| 972 | Chicago White SoxD. Cease -R | -1½ +135 | -139 | U 9 +100 |
| 8:15 PM | ||||
| 959 | Chicago CubsK. Hendricks -R | -1½ +150 | -105 | O 8½ +110 |
| 960 | St. Louis CardinalsA. Wainwright -R | +1½ -170 | -105 | U 8½ -130 |
| 10:10 PM | ||||
| 961 | San Francisco GiantsL. Webb -R | +1½ -130 | +161 | O 8½ -110 |
| 962 | Los Angeles DodgersJ. Urias -L | -1½ +110 | -175 | U 8½ -110 |
