Apr 26 Tue 2022
| 05:35 PM | ||||
| 901 | Milwaukee BrewersB. Woodruff -R | -1½ -110 | -176 | O 7 -105 |
| 902 | Pittsburgh PiratesM. Keller -R | +1½ -110 | +162 | U 7 -115 |
| 05:40 PM | ||||
| 903 | San Diego PadresJ. Musgrove -R | -1½ +100 | -168 | O 8 -105 |
| 904 | Cincinnati RedsR. Sanmartin -L | +1½ -120 | +155 | U 8 -115 |
| 05:45 PM | ||||
| 905 | Colorado RockiesG. Marquez -R | +1½ -150 | +148 | O 8 -110 |
| 906 | Philadelphia PhilliesZ. Eflin -R | -1½ +130 | -160 | U 8 -110 |
| 06:05 PM | ||||
| 907 | Miami MarlinsS. Alcantara -R | -1½ +130 | -135 | O 7½ +100 |
| 908 | Washington NationalsJ. Gray -R | +1½ -150 | +125 | U 7½ -120 |
| 06:05 PM | ||||
| 917 | Baltimore OriolesJ. Lyles -R | +1½ +110 | +241 | O 8 -110 |
| 918 | New York YankeesL. Severino -R | -1½ -130 | -270 | U 8 -110 |
| 06:07 PM | ||||
| 919 | Boston Red SoxN. Pivetta -R | +1½ -120 | +166 | O 8 -115 |
| 920 | Toronto Blue JaysK. Gausman -R | -1½ +100 | -180 | U 8 -105 |
| 06:10 PM | ||||
| 921 | Kansas City RoyalsD. Lynch -L | +1½ -145 | +132 | O 8½ -130 |
| 922 | Chicago White SoxD. Keuchel -L | -1½ +125 | -143 | U 8½ +110 |
| 06:20 PM | ||||
| 909 | Chicago CubsM. Stroman -R | +1½ -140 | +150 | O 8 -105 |
| 910 | Atlanta BravesM. Fried -L | -1½ +120 | -163 | U 8 -115 |
| 06:40 PM | ||||
| 923 | Detroit TigersE. Rodriguez -L | +1½ -170 | +125 | O 7½ +110 |
| 924 | Minnesota TwinsC. Paddack -R | -1½ +150 | -135 | U 7½ -130 |
| 06:45 PM | ||||
| 911 | New York MetsC. Bassitt -R | -1½ +150 | -112 | O 7 -110 |
| 912 | St. Louis CardinalsJ. Hicks -R | +1½ -170 | +102 | U 7 -110 |
| 07:05 PM | ||||
| 925 | Houston AstrosJ. Odorizzi -R | -1½ +145 | -115 | O 9 -120 |
| 926 | Texas RangersT. Hearn -L | +1½ -165 | +105 | U 9 +100 |
| 08:38 PM | ||||
| 927 | Cleveland GuardiansT. McKenzie -R | +1½ -145 | +143 | O 8½ +105 |
| 928 | Los Angeles AngelsP. Sandoval -L+1 Markets | -1½ +125 | -155 | U 8½ -125 |
| 08:40 PM | ||||
| 913 | Los Angeles DodgersT. Gonsolin -R | -1½ -135 | -190 | O 9½ -105 |
| 914 | Arizona DiamondbacksZ. Davies -R | +1½ +115 | +175 | U 9½ -115 |
| 08:45 PM | ||||
| 929 | Oakland AthleticsD. Jefferies -R | +1½ -105 | +216 | O 6½ -110 |
| 930 | San Francisco GiantsC. Rodon -L | -1½ -115 | -240 | U 6½ -110 |