Jul 27 Tue 2021
| 7:05 PM | ||||
| 951 | Milwaukee BrewersB. Anderson -L | -135 | O 9 +100 | |
| 952 | Pittsburgh PiratesT. Anderson -L | +125 | U 9 -120 |
| 7:05 PM | ||||
| 953 | Washington NationalsE. Fedde -R | +105 | O 9½ -120 | |
| 954 | Philadelphia PhilliesM. Moore -L | -115 | U 9½ +100 |
| 7:05 PM | ||||
| 971 | Miami MarlinsS. Alcantara -R | -125 | O 9½ -105 | |
| 972 | Baltimore OriolesS. Watkins -R | +115 | U 9½ -115 |
| 7:10 PM | ||||
| 961 | Toronto Blue JaysR. Ray -L | -120 | O 10 -125 | |
| 962 | Boston Red SoxG. Richards -R | +110 | U 10 +105 |
| 7:10 PM | ||||
| 963 | New York YankeesJ. Montgomery -L | +143 | O 8½ +105 | |
| 964 | Tampa Bay RaysS. McClanahan -L | -155 | U 8½ -125 |
| 7:10 PM | ||||
| 973 | St. Louis CardinalsA. Wainwright -R | +100 | O 9 -115 | |
| 974 | Cleveland IndiansC. Quantrill -R | -110 | U 9 -105 |
| 8:05 PM | ||||
| 975 | Arizona DiamondbacksT. Widener -R | +132 | O 8½ -120 | |
| 976 | Texas RangersD. Dunning -R | -143 | U 8½ +100 |
| 8:10 PM | ||||
| 965 | Detroit TigersT. Alexander -L | +190 | O 9½ +100 | |
| 966 | Minnesota TwinsK. Maeda -R | -208 | U 9½ -120 |
| 8:10 PM | ||||
| 967 | Chicago White SoxD. Cease -R | -135 | O 10 -115 | |
| 968 | Kansas City RoyalsB. Keller -R | +125 | U 10 -105 |
| 9:38 PM | ||||
| 977 | Colorado RockiesA. Gomber -L | +121 | O 9½ -105 | |
| 978 | Los Angeles AngelsJ. Suarez -L | -131 | U 9½ -115 |
| 9:45 PM | ||||
| 959 | Los Angeles DodgersJ. Urias -L | -130 | O 8 -125 | |
| 960 | San Francisco GiantsL. Webb -R | +120 | U 8 +105 |
| 10:10 PM | ||||
| 969 | Houston AstrosL. McCullers Jr. -R | -132 | O 8½ -105 | |
| 970 | Seattle MarinersC. Flexen -R | +122 | U 8½ -115 |
| 10:10 PM | ||||
| 979 | Oakland AthleticsJ. Kaprielian -R | +121 | O 8½ -105 | |
| 980 | San Diego PadresC. Paddack -R | -131 | U 8½ -115 |