Jun 22 Tue 2021
| 1:10 PM | ||||
| 967 | Cincinnati RedsW. Miley -L | -109 | O 9½ -115 | |
| 968 | Minnesota TwinsB. Ober -R | -101 | U 9½ -105 |
| 7:05 PM | ||||
| 959 | Kansas City RoyalsB. Singer -R | +237 | O 8 -110 | |
| 960 | New York YankeesG. Cole -R | -265 | U 8 -110 |
| 7:05 PM | ||||
| 961 | Houston AstrosZ. Greinke -R | -181 | O 10 -125 | |
| 962 | Baltimore OriolesJ. Lopez -R | +166 | U 10 +105 |
| 7:05 PM | ||||
| 969 | Chicago White SoxL. Giolito -R | -165 | O 7½ -110 | |
| 970 | Pittsburgh PiratesT. Anderson -L | +152 | U 7½ -110 |
| 7:10 PM | ||||
| 953 | Atlanta BravesC. Morton -R | -101 | O 7½ +105 | |
| 954 | New York MetsM. Stroman -R | -109 | U 7½ -125 |
| 7:10 PM | ||||
| 963 | Boston Red SoxE. Rodriguez -L | -105 | O 8 -120 | |
| 964 | Tampa Bay RaysA. Kittredge -R | -105 | U 8 +100 |
| 7:10 PM | ||||
| 971 | Toronto Blue JaysR. Stripling -R | -113 | O 7½ -120 | |
| 972 | Miami MarlinsS. Alcantara -R | +103 | U 7½ +100 |
| 7:10 PM | ||||
| 973 | St. Louis CardinalsJ. Oviedo -R | -117 | O 9 -115 | |
| 974 | Detroit TigersT. Skubal -L | +107 | U 9 -105 |
| 8:05 PM | ||||
| 965 | Oakland AthleticsC. Irvin -L | -141 | O 9 -102 | |
| 966 | Texas RangersJ. Lyles -R | +130 | U 9 -118 |
| 9:38 PM | ||||
| 977 | San Francisco GiantsA. Desclafani -R | +115 | O 8½ -110 | |
| 978 | Los Angeles AngelsA. Heaney -L | -125 | U 8½ -110 |
| 9:40 PM | ||||
| 955 | Milwaukee BrewersF. Peralta -R | -143 | O 8½ -105 | |
| 956 | Arizona DiamondbacksZ. Gallen -R | +132 | U 8½ -115 |
| 10:10 PM | ||||
| 979 | Colorado RockiesK. Freeland -L | +136 | O 8 -115 | |
| 980 | Seattle MarinersC. Flexen -R | -147 | U 8 -105 |
