A combined 54 players between the 2 teams are not expected to play tonight.
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A quote from a Vikings site, "The Minnesota Vikings had a fantastic week of joint practices against the San Francisco 49ers. Both teams were uber-competitive and we saw some ferocious battles throughout.
ESPN’s Kevin Seifert mentioned after day two of practice that he wouldn’t be surprised if the Vikings rested their top line players. The idea being they got a lot of reps during practice and didn’t need the in-game reps."
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And from a 49ers site, "The 49ers are playing it very safe in their second preseason contest vs. the Minnesota Vikings on Saturday evening. With another game in Houston just five days away, San Francisco has elected to rest virtually all of their presumed starters."
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I'm guessing both coaches want to get this game over as quickly as possible.