Sep 17 Sat 2022
| 02:07 PM | ||||
| 969 | Baltimore OriolesK. Bradish -R | +1½ -145 | +142 | O 8½ -115 |
| 970 | Toronto Blue JaysJ. Berrios -R | -1½ +125 | -154 | U 8½ -105 |
| 03:05 PM | ||||
| 955 | Miami MarlinsT. Rogers -L | -1½ +135 | -120 | O 8 +100 |
| 956 | Washington NationalsE. Fedde -R | +1½ -155 | +110 | U 8 -120 |
| 03:10 PM | ||||
| 971 | Kansas City RoyalsB. Singer -R | +1½ -145 | +139 | O 9 -105 |
| 972 | Boston Red SoxR. Hill -L | -1½ +125 | -151 | U 9 -115 |
| 05:10 PM | ||||
| 975 | Chicago White SoxJ. Cueto -R | -1½ +115 | -145 | O 7½ -120 |
| 976 | Detroit TigersE. Rodriguez -L | +1½ -135 | +134 | U 7½ +100 |
| 06:10 PM | ||||
| 957 | Pittsburgh PiratesB. Wilson -R | +1½ +120 | +266 | O 8 -105 |
| 958 | New York MetsC. Bassitt -R | -1½ -140 | -300 | U 8 -115 |
| 06:10 PM | ||||
| 979 | Oakland AthleticsC. Irvin -L | +1½ +105 | +237 | O 8 +100 |
| 980 | Houston AstrosJ. Urquidy -R | -1½ -125 | -265 | U 8 -120 |
| 06:10 PM | ||||
| 983 | New York YankeesJ. Taillon -R | +1½ -210 | +108 | O 7½ +100 |
| 984 | Milwaukee BrewersB. Woodruff -R | -1½ +180 | -118 | U 7½ -120 |
| 06:20 PM | ||||
| 961 | Philadelphia PhilliesA. Nola -R | -1½ +160 | -105 | O 8 +100 |
| 962 | Atlanta BravesJ. Odorizzi -R | +1½ -180 | -105 | U 8 -120 |
| 07:10 PM | ||||
| 963 | San Diego PadresJ. Musgrove -R | +1½ -220 | +100 | O 7 -120 |
| 964 | Arizona DiamondbacksZ. Gallen -R | -1½ +190 | -110 | U 7 +100 |
| 08:07 PM | ||||
| 981 | Seattle MarinersG. Kirby -R | +1½ -225 | -106 | O 7 -120 |
| 982 | Los Angeles AngelsS. Ohtani -R | -1½ +195 | -104 | U 7 +100 |