Jul 23 Sat 2022
| 04:10 PM | ||||
| 967 | Houston AstrosJ. Verlander -R | -1½ +137 | -125 | O 7 -115 |
| 968 | Seattle MarinersL. Gilbert -R | +1½ -157 | +115 | U 7 -105 |
| 04:10 PM | ||||
| 969 | Toronto Blue JaysA. Manoah -R | -1½ +130 | -133 | O 9 -120 |
| 970 | Boston Red SoxK. Crawford -R | +1½ -150 | +123 | U 9 +100 |
| 06:05 PM | ||||
| 951 | Chicago CubsM. Stroman -R | +1½ -155 | +137 | O 8 +100 |
| 952 | Philadelphia PhilliesZ. Wheeler -R | -1½ +135 | -148 | U 8 -120 |
| 06:10 PM | ||||
| 971 | Minnesota TwinsJ. Ryan -R | -1½ +100 | -165 | O 8½ -108 |
| 972 | Detroit TigersM. Pineda -R | +1½ -120 | +152 | U 8½ -112 |
| 06:40 PM | ||||
| 953 | St. Louis CardinalsS. Matz -L | -1½ +100 | -155 | O 10½ +105 |
| 954 | Cincinnati RedsM. Minor -L | +1½ -120 | +143 | U 10½ -125 |
| 07:05 PM | ||||
| 955 | Miami MarlinsM. Meyer -R | -1½ +145 | -105 | O 8½ +100 |
| 956 | Pittsburgh PiratesJ. Quintana -L | +1½ -165 | -105 | U 8½ -120 |
| 07:05 PM | ||||
| 973 | New York YankeesG. Cole -R | -1½ -130 | -225 | O 8 -125 |
| 974 | Baltimore OriolesJ. Lyles -R | +1½ +110 | +204 | U 8 +105 |
| 07:10 PM | ||||
| 957 | San Diego PadresB. Snell -L | +1½ -170 | +129 | O 7½ -110 |
| 958 | New York MetsC. Bassitt -R | -1½ +150 | -139 | U 7½ -110 |
| 07:10 PM | ||||
| 959 | Colorado RockiesJ. Urena -R | +1½ +105 | +239 | O 7½ -115 |
| 960 | Milwaukee BrewersB. Woodruff -R | -1½ -125 | -268 | U 7½ -105 |
| 07:15 PM | ||||
| 961 | San Francisco GiantsA. Wood -L | +1½ -140 | +155 | O 8 -115 |
| 962 | Los Angeles DodgersJ. Urias -L | -1½ +120 | -168 | U 8 -105 |
| 07:20 PM | ||||
| 981 | Los Angeles AngelsP. Sandoval -L | +1½ -117 | +170 | O 8½ -115 |
| 982 | Atlanta BravesK. Wright -R | -1½ -103 | -185 | U 8½ -105 |
| 08:10 PM | ||||
| 963 | Washington NationalsA. Sanchez -R | +1½ -165 | +130 | O 9½ +105 |
| 964 | Arizona DiamondbacksM. Bumgarner -L | -1½ +145 | -141 | U 9½ -125 |
| 09:07 PM | ||||
| 979 | Texas RangersT. Hearn -L | -1½ +140 | -121 | O 7½ +100 |
| 980 | Oakland AthleticsJ. Kaprielian -R | +1½ -160 | +111 | U 7½ -120 |